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Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense
https://doi.org/10.18999/nagjms.54.1-4.11
https://doi.org/10.18999/nagjms.54.1-4.11c05aacca-68ad-4f62-a6e1-be96315b4521
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-02-14 | |||||
タイトル | ||||||
タイトル | Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense | |||||
著者 |
YOSHIKAI, YASUNOBU
× YOSHIKAI, YASUNOBU |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | γδ T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | αβ T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 65 kd HSP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Listeria monocytogenes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoimmune disease | |||||
抄録 | ||||||
内容記述 | During infection with L.monocytogenes, a facultative intracellular bacteria, TcR γ/δ T cells specific for 65 kd hsp precede TcR α/β T cells specific for the listerial antigens in appearance. The γ/δ T cells provide a first line of defense against the infection by recognizing exogenous and endogenous 65 kd hsp on infected cells and producing cytokines such as γIFN. The hsp-specific T cells respond quickly to antigenically diverse pathogens before antigen-specific T cells expand clonally, and they play a role in covering the gap between the phagocytic system and highly evolved immune response. 65 kd hsp-specific T cells play important roles not only in host defense mechanism against infection with various pathogens but also in induction of autoimmune disease. Both 65 kd hsp-specific γδ T cells and 65 kd hsp-specific αβ T cells abrogate the unresponsiveness of the self-reactive αβ T cells and/or B cells by producing IL-2 and contribute to induction of autoimmune disease. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.54.1-4.11 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 54, 号 1-4, p. 11-26, 発行日 1992-03 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5414/5414.html | |||||
識別子タイプ | URI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/17519 | |||||
識別子タイプ | HDL |