@article{oai:nagoya.repo.nii.ac.jp:00015501, author = {YOSHIKAI, YASUNOBU}, issue = {1-4}, journal = {Nagoya Journal of Medical Science}, month = {Mar}, note = {During infection with L.monocytogenes, a facultative intracellular bacteria, TcR γ/δ T cells specific for 65 kd hsp precede TcR α/β T cells specific for the listerial antigens in appearance. The γ/δ T cells provide a first line of defense against the infection by recognizing exogenous and endogenous 65 kd hsp on infected cells and producing cytokines such as γIFN. The hsp-specific T cells respond quickly to antigenically diverse pathogens before antigen-specific T cells expand clonally, and they play a role in covering the gap between the phagocytic system and highly evolved immune response. 65 kd hsp-specific T cells play important roles not only in host defense mechanism against infection with various pathogens but also in induction of autoimmune disease. Both 65 kd hsp-specific γδ T cells and 65 kd hsp-specific αβ T cells abrogate the unresponsiveness of the self-reactive αβ T cells and/or B cells by producing IL-2 and contribute to induction of autoimmune disease.}, pages = {11--26}, title = {Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense}, volume = {54}, year = {1992} }