{"created":"2021-03-01T06:22:41.600148+00:00","id":15501,"links":{},"metadata":{"_buckets":{"deposit":"34c3ea18-25ea-4f2c-892c-64a9446e340f"},"_deposit":{"created_by":17,"id":"15501","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15501"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00015501","sets":["499:508:509:1465"]},"author_link":["47286"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"26","bibliographicPageStart":"11","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"During infection with L.monocytogenes, a facultative intracellular bacteria, TcR γ/δ T cells specific for 65 kd hsp precede TcR α/β T cells specific for the listerial antigens in appearance. The γ/δ T cells provide a first line of defense against the infection by recognizing exogenous and endogenous 65 kd hsp on infected cells and producing cytokines such as γIFN. The hsp-specific T cells respond quickly to antigenically diverse pathogens before antigen-specific T cells expand clonally, and they play a role in covering the gap between the phagocytic system and highly evolved immune response. 65 kd hsp-specific T cells play important roles not only in host defense mechanism against infection with various pathogens but also in induction of autoimmune disease. Both 65 kd hsp-specific γδ T cells and 65 kd hsp-specific αβ T cells abrogate the unresponsiveness of the self-reactive αβ T cells and/or B cells by producing IL-2 and contribute to induction of autoimmune disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/17519"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.54.1-4.11","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5414/5414.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YOSHIKAI, YASUNOBU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47286","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v54n14p11_26.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v54n14p11_26.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/15501/files/v54n14p11_26.pdf"},"version_id":"2bd1f04f-ff27-4919-bec3-02c6a141325b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"γδ T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"αβ T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"65 kd HSP","subitem_subject_scheme":"Other"},{"subitem_subject":"Listeria monocytogenes","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmune disease","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1465"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-14"},"publish_date":"2013-02-14","publish_status":"0","recid":"15501","relation_version_is_last":true,"title":["Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:51:10.810189+00:00"}