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Cerebellar Hypoplasia in the Hyperbilirubinemic Gunn Rat: Morphological Aspects
https://doi.org/10.18999/nagjms.55.1-4.11
https://doi.org/10.18999/nagjms.55.1-4.11c2b99887-83c9-45fe-9a8c-3ae49d67171f
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-02-14 | |||||
タイトル | ||||||
タイトル | Cerebellar Hypoplasia in the Hyperbilirubinemic Gunn Rat: Morphological Aspects | |||||
著者 |
YAMAMURA, HIDEKI
× YAMAMURA, HIDEKI× TAKAGISHI, YOSHIKO |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gunn rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bilirubin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebellar hypoplasia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Purkinje cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Synaptogenesis | |||||
抄録 | ||||||
内容記述 | Gunn rats, a mutant strain of rats, suffer from autosomal recessive hyperbilirubinemia. The homozygotes (j/j) develop jaundice soon after birth and often exhibit kernicterus and cerebellar hypoplasia that are due to bilirubin. Therefore, j/j Gunn rats have been used as an animal model of bilirubin encephalopathy, as well as of neonatal hyperbilirubinemia. In this review, we discuss morphological aspects of the cerebellar hypoplasia that is due to bilirubin and describe the relationship between plasma bilirubin levels and cerebellar hypoplasia, as well as the pathogenesis of cerebellar hypoplasia, including abnormal histogenesis of the cerebellar cortex, abnormalities associated with Purkinje cells and abnormal synaptogenesis in j/j Gunn rats. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.55.1-4.11 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5514/5514.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 55, 号 1-4, p. 11-21, 発行日 1993-03 |
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著者版フラグ | ||||||
値 | publisher |