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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 55(1-4)

Hepatic Copper Accumulation in Patients with Primary Biliary Cirrhosis

https://doi.org/10.18999/nagjms.55.1-4.115
https://doi.org/10.18999/nagjms.55.1-4.115
c8c84d95-371a-41a7-af14-abef32d6f37e
名前 / ファイル ライセンス アクション
v55n14p115_123.pdf v55n14p115_123.pdf (915.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-18
タイトル
タイトル Hepatic Copper Accumulation in Patients with Primary Biliary Cirrhosis
著者 TAKESHIMA, HIROTOMO

× TAKESHIMA, HIROTOMO

WEKO 98764

TAKESHIMA, HIROTOMO

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YAGI, AKIRA

× YAGI, AKIRA

WEKO 98765

YAGI, AKIRA

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YANO, MOTOYOSHI

× YANO, MOTOYOSHI

WEKO 98766

YANO, MOTOYOSHI

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SAKAMOTO, NOBUO

× SAKAMOTO, NOBUO

WEKO 98767

SAKAMOTO, NOBUO

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KATO, SHOSHI

× KATO, SHOSHI

WEKO 98768

KATO, SHOSHI

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KURIKI, JUNSUKE

× KURIKI, JUNSUKE

WEKO 98769

KURIKI, JUNSUKE

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ARAO, MOTOHIRO

× ARAO, MOTOHIRO

WEKO 98770

ARAO, MOTOHIRO

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TAKIKAWA, TOSHIKUNI

× TAKIKAWA, TOSHIKUNI

WEKO 98771

TAKIKAWA, TOSHIKUNI

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HAYASHI, HISAO

× HAYASHI, HISAO

WEKO 98772

HAYASHI, HISAO

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キーワード
主題Scheme Other
主題 Primary biliary cirrhosis
キーワード
主題Scheme Other
主題 Copper
キーワード
主題Scheme Other
主題 Cuproprotein
キーワード
主題Scheme Other
主題 Ursodeoxycholic acid
抄録
内容記述 Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes and on the binding ratio of postulated copper transfer proteins between the cytosol and Iysosomes. Eight patients were in stage 1 with an initial accumulation of lysosomal cuproproteins, mediated by transfer proteins not saturated with copper. Two patients were in stage 2, in which transfer proteins were saturated with copper. The first two stages gave negative results for histochemical copper. The remaining eight patients were in stage 3, in which copper accumulation detected by histochemical included transfer proteins saturated with copper and large amounts of lysosomal cuproproteins. Five patients (one each in stages 1 and 2, and three in stage 3) underwent a second liver biopsy after treatment with 600 mg of ursodeoxycholic acid daily for 14 to 39 months. Results of blood chemistry tests improved, but liver histologic findings and copper accumulation were unchanged in all five patients. It seems likely that ursodeoxycholic acid does not affect the copper accumulation in hepatocyte lysosomes that reflects the state of cholestasis in patients with primary biliary cirrhosis.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.55.1-4.115
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5514/5514.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 55, 号 1-4, p. 115-123, 発行日 1993-03
著者版フラグ
値 publisher
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