ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "f9ed656f-fcc2-46e8-a207-e0310d2028bd"}, "_deposit": {"id": "15524", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "15524"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00015524", "sets": ["1466"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-4", "bibliographicPageEnd": "130", "bibliographicPageStart": "125", "bibliographicVolumeNumber": "55", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To analyze the processes of the development of thymoma and malignant thymoma from normal thymic epithelial cells, we have examined the expression of 15 proto-oncogenes and tumor suppressor genes in seven in vitro epithelial cell lines established from a normal thymus (TuD1-1, TuD1-3, and TuD1-5), thymoma (TaD1-3 and TaD1-8), and malignant thymoma (MTHC-1 and MTHC-3) of rats. Northern blot analysis indicated that most of these genes examined were transcribed at similar levels. However, higher levels of transcription of epidermal growth factor receptor (EGFR) were observed in TuD1-1, TuD1-3, TuD1-5, TaD1-3, and TaD1-8 cells than in MTHC-1 and MTHC-3 cells. Conversely, four of the former five cell lines showed no TGF-β transcription while the latter two cell lines had high levels of its expression. In addition, c-fos proto-oncogene was highly expressed in TuD1-5 cells, which showed the fastest growth rate among the seven cell lines. These results denote that some molecular changes in the regulation of gene expression occurred in the processes of malignant transformation of thymic epithelial cells.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.55.1-4.125", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "異版である", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5514/5514.html", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN(Online)", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SAKAI, YOSHIHISA"}], "nameIdentifiers": [{"nameIdentifier": "98758", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WAJJWALKUI, WORAWIDH"}], "nameIdentifiers": [{"nameIdentifier": "98759", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAKAHASHI, MASAHIDE"}], "nameIdentifiers": [{"nameIdentifier": "98760", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MASUDA, AKIRA"}], "nameIdentifiers": [{"nameIdentifier": "98761", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UTSUMI, R. KAZUHIKO"}], "nameIdentifiers": [{"nameIdentifier": "98762", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MATSUYAMA, MUTSUSHI"}], "nameIdentifiers": [{"nameIdentifier": "98763", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v55n14p125_130.pdf", "filesize": [{"value": "752.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 752600.0, "url": {"label": "v55n14p125_130.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/15524/files/v55n14p125_130.pdf"}, "version_id": "af884f53-fe42-4929-9735-1d55a12c45a1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Thymoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Malignant thymoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Expression of EGFR, TGF-β and c-fos", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BUF/Mna rat", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats"}]}, "item_type_id": "9", "owner": "1", "path": ["1466"], "permalink_uri": "https://doi.org/10.18999/nagjms.55.1-4.125", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-02-18"}, "publish_date": "2013-02-18", "publish_status": "0", "recid": "15524", "relation": {}, "relation_version_is_last": true, "title": ["Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats"], "weko_shared_id": null}
  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 55(1-4)

Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats

https://doi.org/10.18999/nagjms.55.1-4.125
https://doi.org/10.18999/nagjms.55.1-4.125
99b311a0-5fe1-41f1-a270-70f1b7a2d4af
名前 / ファイル ライセンス アクション
v55n14p125_130.pdf v55n14p125_130.pdf (752.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-18
タイトル
タイトル Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats
著者 SAKAI, YOSHIHISA

× SAKAI, YOSHIHISA

WEKO 98758

SAKAI, YOSHIHISA

Search repository
WAJJWALKUI, WORAWIDH

× WAJJWALKUI, WORAWIDH

WEKO 98759

WAJJWALKUI, WORAWIDH

Search repository
TAKAHASHI, MASAHIDE

× TAKAHASHI, MASAHIDE

WEKO 98760

TAKAHASHI, MASAHIDE

Search repository
MASUDA, AKIRA

× MASUDA, AKIRA

WEKO 98761

MASUDA, AKIRA

Search repository
UTSUMI, R. KAZUHIKO

× UTSUMI, R. KAZUHIKO

WEKO 98762

UTSUMI, R. KAZUHIKO

Search repository
MATSUYAMA, MUTSUSHI

× MATSUYAMA, MUTSUSHI

WEKO 98763

MATSUYAMA, MUTSUSHI

Search repository
キーワード
主題Scheme Other
主題 Thymoma
キーワード
主題Scheme Other
主題 Malignant thymoma
キーワード
主題Scheme Other
主題 Expression of EGFR, TGF-β and c-fos
キーワード
主題Scheme Other
主題 BUF/Mna rat
抄録
内容記述 To analyze the processes of the development of thymoma and malignant thymoma from normal thymic epithelial cells, we have examined the expression of 15 proto-oncogenes and tumor suppressor genes in seven in vitro epithelial cell lines established from a normal thymus (TuD1-1, TuD1-3, and TuD1-5), thymoma (TaD1-3 and TaD1-8), and malignant thymoma (MTHC-1 and MTHC-3) of rats. Northern blot analysis indicated that most of these genes examined were transcribed at similar levels. However, higher levels of transcription of epidermal growth factor receptor (EGFR) were observed in TuD1-1, TuD1-3, TuD1-5, TaD1-3, and TaD1-8 cells than in MTHC-1 and MTHC-3 cells. Conversely, four of the former five cell lines showed no TGF-β transcription while the latter two cell lines had high levels of its expression. In addition, c-fos proto-oncogene was highly expressed in TuD1-5 cells, which showed the fastest growth rate among the seven cell lines. These results denote that some molecular changes in the regulation of gene expression occurred in the processes of malignant transformation of thymic epithelial cells.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.55.1-4.125
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5514/5514.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 55, 号 1-4, p. 125-130, 発行日 1993-03
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 09:13:15.726014
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3