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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 75(1-2)

No Association between MTHFR C677T and Serum Uric Acid Levels among Japanese with ABCG2 126QQ and SLC22A12 258WW

https://doi.org/10.18999/nagjms.75.1-2.93
https://doi.org/10.18999/nagjms.75.1-2.93
cdeacf08-987a-4ed7-80da-797c2ff3366f
名前 / ファイル ライセンス アクション
10_Hinohara.pdf 10_Hinohara.pdf (130.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-03-01
タイトル
タイトル No Association between MTHFR C677T and Serum Uric Acid Levels among Japanese with ABCG2 126QQ and SLC22A12 258WW
著者 HINOHARA, YUKAKO

× HINOHARA, YUKAKO

WEKO 47483

HINOHARA, YUKAKO

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NAITO, MARIKO

× NAITO, MARIKO

WEKO 47484

NAITO, MARIKO

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OKADA, RIEKO

× OKADA, RIEKO

WEKO 47485

OKADA, RIEKO

Search repository
YIN, GUAN

× YIN, GUAN

WEKO 47486

YIN, GUAN

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HIGASHIBATA, TAKAHIRO

× HIGASHIBATA, TAKAHIRO

WEKO 47487

HIGASHIBATA, TAKAHIRO

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TAMURA, TAKASHI

× TAMURA, TAKASHI

WEKO 47488

TAMURA, TAKASHI

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KAWAI, SAYO

× KAWAI, SAYO

WEKO 47489

KAWAI, SAYO

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MORITA, EMI

× MORITA, EMI

WEKO 47490

MORITA, EMI

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WAKAI, KENJI

× WAKAI, KENJI

WEKO 47491

WAKAI, KENJI

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MATSUO, HIROTAKA

× MATSUO, HIROTAKA

WEKO 47492

MATSUO, HIROTAKA

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MORI, ATSUYOSHI

× MORI, ATSUYOSHI

WEKO 47493

MORI, ATSUYOSHI

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HAMAJIMA, NOBUYUKI

× HAMAJIMA, NOBUYUKI

WEKO 47494

HAMAJIMA, NOBUYUKI

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キーワード
主題Scheme Other
主題 Serum uric acid
キーワード
主題Scheme Other
主題 Urate transporter polymorphisms
キーワード
主題Scheme Other
主題 MTHFR C677T
抄録
内容記述 Several genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) of ABCG2 and SLC22A12 were strongly associated with serum uric acid (SUA), but those of methylene tetrahydrofolate reductase (MTHFR) were not. However, there were several studies indicating the association with MTHFR C677T polymorphism. This study examined the association with the polymorphism, taking into account the genotypes of ABCG2 Q126X and SLC22A12 W258X. Subjects were 5,028 health checkup examinees of Seirei Preventive Health Care Center (3,416 males and 1,612 females) aged 35 to 69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). Hyperuricemia was defined as SUA equal to 7 mg/dL or over. The genotype frequency was 35.9% for CC, 48.1% for CT, and 16.0% for TT, being in Hardy-Weinberg equilibrium (p=0.90). Among 4,425 participants with ABCG2 126QQ and SLC22A12 258WW who were not under medication for hyperuricemia, the mean SUA was 5.6 mg/dL, 5.6 mg/dL, and 5.7 mg/dL, respectively. When 114 participants with ABCG2 126QQ and SLC22A12 258WW under medication for hyperuricemia were included in hyperuricemia cases, the sex-age adjusted odds ratio (OR) of hyperuricemia was not significant; OR=1.00 (95% confidence interval, 0.89–1.24) for CT genotype and OR=0.98 (0.84–1.32) for TT genotype, relative to CC genotype. The present study indicated no association between SUA and MTHFR C677T genotype, after the influences of ABCG2 Q126X and SLC22A12 W258X were removed.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.75.1-2.93
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 75, 号 1-2, p. 93-100, 発行日 2013-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17605
識別子タイプ HDL
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