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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 75(3-4)

INCREASING AND DECREASING PHASES OF FERRITIN AND HEMOSIDERIN IRON DETERMINED BY SERUM FERRITIN KINETICS

https://doi.org/10.18999/nagjms.75.3-4.213
https://doi.org/10.18999/nagjms.75.3-4.213
871631e8-9dd2-49ec-9fb6-9424d016284f
名前 / ファイル ライセンス アクション
06_Saito.pdf 06_Saito.pdf (600.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-09-12
タイトル
タイトル INCREASING AND DECREASING PHASES OF FERRITIN AND HEMOSIDERIN IRON DETERMINED BY SERUM FERRITIN KINETICS
著者 Saito, Hiroshi

× Saito, Hiroshi

WEKO 49228

Saito, Hiroshi

Search repository
Hayashi, Hisao

× Hayashi, Hisao

WEKO 49229

Hayashi, Hisao

Search repository
Tomita, Akihiro

× Tomita, Akihiro

WEKO 49230

Tomita, Akihiro

Search repository
Ohashi, Haruhiko

× Ohashi, Haruhiko

WEKO 49231

Ohashi, Haruhiko

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Maeda, Hideaki

× Maeda, Hideaki

WEKO 49232

Maeda, Hideaki

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Naoe, Tomoki

× Naoe, Tomoki

WEKO 49233

Naoe, Tomoki

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キーワード
主題Scheme Other
主題 Serum ferritin kinetics
キーワード
主題Scheme Other
主題 Recovery of ferritin iron
キーワード
主題Scheme Other
主題 Transformation of ferritin into hemosiderin
キーワード
主題Scheme Other
主題 Increasing and decreasing phases of iron stores
キーワード
主題Scheme Other
主題 Iron in chronic hepatitis C
抄録
内容記述 We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial stage, but it was slow later. In contrast, the change of hemosiderin iron was slow in the initial stage, but it became rapid later. These changes of ferritin and hemosiderin iron suggest that the turnover of ferritin iron is preferential to that of hemosiderin iron, and that the initially existed ferritin iron is gradually replaced by the ferritin iron recovered by taking iron from hemosiderin in iron mobilization. The crossing of the increasing curves of ferritin and hemosiderin iron in iron addition indicates a switching of the principal storage iron from ferritin to hemosiderin. The crossing point shifted toward a higher storage iron level in the increase of iron deposition. Iron storing capacity can be increased not only by the transformation of ferritin into hemosiderin, but also by the expansion of cell space as seen by hepatomegaly in hereditary hemochromatosis. The amounts of hemosiderin iron exceeded ferritin iron in all 10 patients with chronic hepatitis C even though they had normal storage iron levels. This suggests it is difficult to store iron in the form of ferritin in chronic hepatitis C.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.75.3-4.213
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 75, 号 3-4, p. 213-223, 発行日 2013-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7534/7534.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/18470
識別子タイプ HDL
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