@article{oai:nagoya.repo.nii.ac.jp:00016493,
 author = {SUZUKI, KAZUO},
 issue = {1},
 journal = {Nagoya Journal of Medical Science},
 month = {Jun},
 note = {Many facts have been reported, that heat destroys some tumors and potentiates the effects of radiation on tumors. Recently, it was also showed in vitro, that heat enhances the effects of anticancer drugs. The first part of this work was designed to define this in vivo. Heat applied for 30 minutes inhibited the growth of Yoshida solid sarcoma implanted on the feet of rats and enhanced the Nitromin effectiveness on them at more than 42℃. Heat has been applied also to the regional perfusions to promote the action of chemotherapeutic agents. In the second part of this work, with the hyperthermic perfusions of the hind limbs of dogs, the tissue temperature could be elevated to up to 42℃ without complications. These perfusions produced homogeneous distribution of temperature and did not affect the systemic temperature. The hyperthermic perfusion, therefore, was a most suitable method for local heating in combination with cancer chemotherapy. At the same time, elevated temperatures enhanced the action of Nitromin on normal tissue. The determination of the dose of drug should be carefully considered in hyperthermic perfusion.},
 pages = {1--21},
 title = {Application of Heat to Cancer Chemotherapy : Experimental Studies},
 volume = {30},
 year = {1967}
}