@article{oai:nagoya.repo.nii.ac.jp:00016499, author = {ADACHI, FUMIO}, issue = {1}, journal = {Nagoya Journal of Medical Science}, month = {Jun}, note = {Electron microscopic findings on the senile hepatic cells of rats were compared with those of young adult rats in the resting and regenerating stages 6 and 24 hours after partial hepatectomy. In the resting senile hepatic cells, there were found some bizarre mitochondria, and mitochondria were significantly larger in size, and also slightly decreased in number than in the young adult. In the regenerating stage, especially 6 hours after removal, mitochondria of the hepatic cells became irregular in shape more markedly in the senile cases, and in some of the cases, degenerative pictures of mitochondria were occasionally observed in this period. In the regenerating hepatic cells, mitochondria do not increase in size, but are rather reduced. The decrease in size of mitochondria was more marked in the liver of senile cases 24 hours after partial hepatectomy. The decrease in number of mitochondria was observed 24 hours after removal, and the decrease was somewhat marked in the senile cases. In this experiment, the pictures of so-called transverse division of mitochondria were found without any significant difference due to age and the stage of regeneration of hepatic cells. The small osmiophilic bodies considered to be the precursor of fat droplets appeared in the space of Disse, and in the cytoplasm. Their appearances were more markedly noted in the aged than in the young adult at 6 hours of regeneration.}, pages = {109--120}, title = {Electron Microscopic Investigation of the Regenerating Hepatic Cells of the Senile Rat}, volume = {30}, year = {1967} }