@article{oai:nagoya.repo.nii.ac.jp:00016535,
 author = {OSADA, TAKUJI},
 issue = {2},
 journal = {Nagoya Journal of Medical Science},
 month = {Sep},
 note = {In order to observe the effect of hyperbaric oxygenation (ORP) on malignant tumors, the generation time of the Yoshida sarcoma cells was measured under various in vivo conditions. The sarcoma cells transplanted in Donryu rats were divided into 9 groups, which were accordingly exposed to OHPx1, OHPx3, NMO (1 mg/kg)x1, NMO+OHPx1, NMO+OHPx3, MMC (0.5 mg/kg)x1, MMC+OHP x1, and MMC+OHPx3, leaving a group as the control. They were served for the observation of frequency of labeled metaphases, the grain count, and mitotic index of the cells using autoradiography. In the groups of 1 and 3 times of ORP treatment, there were observed the suppression of mitosis, and the prolongation of generation time especially of S phase, due to impaired DNA synthesis. The combination of NMO and OHP rendered more intense suppression of mitosis and more marked prolongation of the generation time than did the NMO treatment alone. By combined treatment of MMC and OHP, the suppression of mitosis and the impairment of DNA synthesis were more marked than by MMC treatment alone. These results suggested the effectiveness of 0HP as an adjuvant to chemotherapy.},
 pages = {243--276},
 title = {A Study on the Effect of Hyperbaric Oxygenation on Yoshida Sarcoma : Especially on Its Influence on the Generation Time},
 volume = {31},
 year = {1968}
}