@article{oai:nagoya.repo.nii.ac.jp:00016536, author = {YAMAUCHI, NOBORU}, issue = {2}, journal = {Nagoya Journal of Medical Science}, month = {Sep}, note = {In order to elucidate the mechanism by which thyroid hormone influences the calcium metabolism, 45Ca kinetic study and calcium, phosphorus and nitrogen balance study were carried out in 4 control subjects, 4 hyperthyroid patients, a hyperthyroid patient associated with hypoparathyroidism, 2 hypothyroid patients and 2 primary hyperparathyroid patients. The conceptual model used to analize the kinetic data was that proposed by Heaney et al. and 45Ca was counted by Lutwak's method, using a liquid scintillation spectrometer. The sizes of miscible calcium pool, the turnover rates, the bone formation rates and the bone resorption rates were increased in hyperthyroid patients as much as in primary hyperparathyroid patients, while these were decreased in hypothyroid patients. Moreover, the bone resorption rates exceeded the bone formation rates in patients with hyperthyroidism as well as in patients with primary hyperparathyroidism. Negative calcium, phosphorus and nitrogen balances were observed in hyperthyroid patients as well as in primary hyperparathyroid patients. From these observations, it was suggested that the excessive destruction of bone is the primary event in the abnormal calcium metabolism in hyperthyroidism.}, pages = {277--290}, title = {45Ca Kinetic Study in Patients with Thyroid Dysfunction}, volume = {31}, year = {1968} }