@article{oai:nagoya.repo.nii.ac.jp:00016584, author = {KATO, KANEFUSA}, issue = {1}, journal = {Nagoya Journal of Medical Science}, month = {Jul}, note = {Fatty acid synthesis in KK mouse, which exhibits a hereditary obese-hyperglycemic syndrome, was studied. Incorporation of [U-14C] glucose into liver fatty acid in vivo was more than four times higher in KK compared with control mice (CF1), but no significantly increased incorporation was observed into carcass fatty acid. Incorporation of [1-14C] acetate into liver fatty acid in vivo was also elevated (5 fold) in KK mice. Fatty acid synthesis from acetate by liver slices of KK mice was about three times higher than that of control. However, the con- version of acetate into fatty acid in adipose tissues from KK mice in vitro was lower than that of control. Level of Liver acetyl CoA carboxylase was twice as high in KK, but with the activity of liver citrate-cleavage enzyme, no difference was observed between KK and control mouse. Mechanisms of hyperlipogenesis in the liver of KK mouse were discussed in relation to hyperinsulinemia and hyperglycemia.}, pages = {129--141}, title = {Studies on Lipogenesis in Hereditary Obese-Hyperglycemic Mice (KK Strain)}, volume = {32}, year = {1969} }