@article{oai:nagoya.repo.nii.ac.jp:00016585,
 author = {NAKASHIMA, KUNIO},
 issue = {1},
 journal = {Nagoya Journal of Medical Science},
 month = {Jul},
 note = {Hepatic glycolytic and gluconeogenic metabolites and enzymes were assayed in obese·hyperglycemic mice (KK), alloxan diabetic mice, and the control mice. Alloxan diabetic mice showed distinctly decreased and increased concentrations of metabolites in fed and starved conditions respectively. There were no differences between KK and the control in these conditions. But in glucose load tests, KK showed the retention of hepatic metabolites in the metabolic pathway of glycolysis at five positions. They were glucose, fructose-6-phosphate, glyceraldehyde-3-phosphate, 2-phosphoglycerate, and oxaloacetic acid. This phenomenon was also observed in alloxan diabetes. In alloxan diabetes, glucokinase, and pyruvate kinase activities were lowered while glucose-6-phosphatase and fructose-1, 6-diphosphatase activities were higher by 75% and 45%, respectively. On the contrary, KK mice showed higher glucokinase and hexokinase activities than the control by 20% as well as higher glucose-6-phosphatase activity (50% increase). Concentrations of corticosterone in the serum were the same levels in KK and the control while insulin-like activity was higher in KK. NAD+/NADH ratio in hepatic cytoplasm suggested the increased reaction in the direction of a-glycerophosphate in KK. High level of cytoplasm ATPIAMP ratio was supposed to be the cause of depression of glycolysis. And this might elevate the citrate concentration resulting in increased fatty acid synthesis.},
 pages = {143--158},
 title = {Glycolytic and Gluconeogenic Metabolites and Enzymes in the Liver of Obese-Hyperglycemic Mice (KK) and Alloxan Diabetic Mice},
 volume = {32},
 year = {1969}
}