{"created":"2021-03-01T06:23:51.814672+00:00","id":16594,"links":{},"metadata":{"_buckets":{"deposit":"a7bb0f4b-4132-44a7-ab3f-e4887963b0f9"},"_deposit":{"created_by":17,"id":"16594","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"16594"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00016594","sets":["499:508:509:1514"]},"author_link":["98569"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1970-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"345","bibliographicPageStart":"327","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Since Glavind reported the existence of peroxides in the atheroma, many investigatiors have become concerned with the studies of peroxides in atherogenesis. But the investigation of this problem is not yet complete. There exist in the living body SH compounds and antioxidants which inhibit the production and in- crease of lipoperoxides. In this paper, the changes of the antioxidant in the living body were investigated whether lipoperoxides have a role in atherogenesis or not. I investigated in rabbits the changes of SH compounds and ascorbic acid in the aorta, liver, and serum following cholesterol feeding and analysed the polarographic protein wave activity of the serum for the estimation of SH compounds. Topographical investigation on SH compounds and ascorbic acid were made with histochemical method on the atherosclerotic rabbit aorta. The changes of these compounds in the serum were investigated on the atherosclerotic patients. In the aorta and serum of the rabbits, SH content was decreased after the cholesterol feeding. The content of ascorbic acid was not changed in the serum, but increased.in the aorta. The decrease in polarographic protein wave activity was observed in the serum. SDH activity decreased in the aorta. The decrease of SDH activity in the liver followed the decrease in the aorta. In the liver of the cholesterol-fed rabbit, no significant difference of SH and ascorbic acid content was observed compared with the control rabbit. Staining intensity of SH compounds and SDH was decreased in the intima and the inner media, but that of ascorbicacid was increased. In the serum of the atherosclerotic patients, SH content tended to decrease. No significant difference of ascorbic acid content was found between the atherosclerotic ahd the nonsclerotic subjects. It is assumed that in the course of atherosclerosis the denaturation of the proteins in the aorta and serum might be induced. This denaturation might be caused by nonenzymatic action of lipoperoxides.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.32.2.327","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/322/322.html ","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IWAHASHI, HIROSHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98569","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v32n2p327_345.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v32n2p327_345.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/16594/files/v32n2p327_345.pdf"},"version_id":"84208486-78ca-42f9-9bf0-3ff167814a61"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Studies on Antioxidants in Atherosclerosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Studies on Antioxidants in Atherosclerosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1514"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-04"},"publish_date":"2013-10-04","publish_status":"0","recid":"16594","relation_version_is_last":true,"title":["Studies on Antioxidants in Atherosclerosis"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:29:16.174207+00:00"}