@article{oai:nagoya.repo.nii.ac.jp:00016597,
 author = {HASEGAWA, HITOSHI and KAMIYA, OSAMU and NAGASE, HIROAKI and TAKIKAWA, KIYOHARU},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {An attempt has been made to detect antibodies to aminopyrine or its derivatives (pyrazolone derivatives) with a passive hemagglutination assay system. Formalinized red blood cells were sensitized by coupling diazotized 4-aminoantipyrine to the surface membrane. With this method, circulating antibodies were detected in a patient with aminopyrine-induced agranulocytosis. Serial determinations revealed that the concentration of antibody increased rapidly after the onset of clinical manifestations, reaching a maximum in about a week, and thereafter began to fall off gradually. The presence of antibody was found in 32 sera of 75 patients with a history of skin reaction due to aminopyrine or its analogues and in 15 sera of 62 control subjects having no such history. The highest hemagglutination titer was 1 : 16.},
 pages = {379--386},
 title = {Detection of Serum Antibodies to Aminopyrine or its Derivatives by a Passive Hemagglutination Assay Method},
 volume = {32},
 year = {1970}
}