@article{oai:nagoya.repo.nii.ac.jp:00016602,
 author = {NAGAMINE, KOICHI},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {Since the experiences of severe side effects of peridurographic examination have been reported, this procedure has been used less frequently in spite of its easy to get. The most remarkable symptoms of accidents were clonic convnlsion, disturbances of speech and consciousness, headache, hyperperspiration and myalgia. Physical examinations revealed always increase of tendon reflex and sometimes pathologic reflex. The accidents could be caused by intraspinal administration of water-soluble contrast medium (Diatrizoate), and also there is a report that there was an accident only when contrast medium was injected in the cranial portion of the subarachnoid space. Contrast medium permeates through the dura mater. Its permeability rate was about 0.4％ in the patient with normal meninges. Since some agents which affect carbohydrate metabolism was found to cause acute convulsion, and decrease of ATP production or ATP utilization was considered to have close relation to consciousness, the effects of the contrast medium on hexokinase activity and mitochondrial respiration of rat brain were examined, and noticeable inhibitory effects were found. The inhibitory effect on D-amino acid oxidase was also observed. The medium had no effects on the succinic dehydrogenase activity, but it had remarkable effects on the state 3 respiration, and decrease of P:0 ratio indicated decrease of ATP production. These results suggest that the watersoluble contrast medium, which is injected in the subarachnoid space, stimulates the cerebral cortex and produces the metabolic disturbances of the brain which might have some relation to development of the accidents.},
 pages = {429--444},
 title = {Clinical and Biochemical Study of Accidents in Peridurography},
 volume = {32},
 year = {1970}
}