@article{oai:nagoya.repo.nii.ac.jp:00016648,
 author = {NAKAMURA, SHINYA},
 issue = {2},
 journal = {Nagoya Journal of Medical Science},
 month = {Sep},
 note = {In Part I the concentrations of sodium and potassium were examined under the same conditions of diuresis and antidiuresis. In the present paper Na-K ATPase activity was assayed under these conditions in order to evaluate the transport of sodium and potassium by the renal tubules. Both furosemide and ethacrynic acid decreased Na-K ATPase activity in the whole homogenates of the cortex, medulla and papilla, in the cortical mitochondrial and microsomal fractions, by intravenous administration. This finding indicates that these agents produce marked diuresis by inhibiting Na·K ATPase activity. With respect to osmotic diuresis both 5% and 20% mannitol also decreased Na·K ATPase activity in all of the parts. On the other hand, both 5% and 50% glucose did not affect Na-K ATPase activity. Judging from these results, it would be sure that mannitol produces diuresis by inhibiting· Na-K ATPase and has a different mode of action on diuresis from that of glucose. With respect to antidiuresis, a low dose of vasopressin (0.1 U/kg) did not affect Na-K A TPase activity, but a high dose of vasopressin (10 U/ kg) decreased it in the whole homogenates of cortex, medulla and papilla, in the cortical mitochondrial and microsomal fractions. This decrease would be partly dependent upon the renal blood flow. It was reported in Part I that the sodium and potassium contents were increased, but Na-K ATPase activity was decreased in this work. This result would show that Na-K ATPase is independent of the reabsorption of sodium and potassium caused by administration of vasopressin. It would also be supposed that the energy required for reabsorption of sodium would be supplied at least in part by a pathway other than of ATP.},
 pages = {163--182},
 title = {Experimental Study on Sodium and Potassium Concentration Gradient and Na-K Dependent Adenosine Triphosphatase Activity in the Kidney : Part II. On Na-K Dependent Adenosine Triphosphatase Activity in the Kidney Undergoing Diuresis and Antidiuresis},
 volume = {34},
 year = {1971}
}