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Study on the Sensitivity Test of Carcinostatic Agents by Acid Phosphatase Activity
https://doi.org/10.18999/nagjms.34.4.315
https://doi.org/10.18999/nagjms.34.4.31589dc312b-d77e-4d66-ba42-23e522bcbc50
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-10-16 | |||||
タイトル | ||||||
タイトル | Study on the Sensitivity Test of Carcinostatic Agents by Acid Phosphatase Activity | |||||
言語 | en | |||||
著者 |
IMAIZUMI, MUNEHISA
× IMAIZUMI, MUNEHISA |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | A new method of tumor sensitivity test by measurement of the activity of acid phosphatase was presented. Treatment of experimental tumor cells with mitomycin C, chromomycin A3 and 5-fiuorouracil showed that deviation index of the specific activity ran well parallel with viability of the cells in vitro. The deviation index of tumor cells was also in agreement with survival times of tumor bearing mice treated with these drugs. Side effects appeared in animals having high values of deviation indices of liver cells. The effectiveness of the drugs was expressed by the values obtained from tumor cells minus those obtained from liver cells. In case of cyclophosphamide, however, it was difficult to judge by this method. In the therapy with mitomycin C, the response was well correlated with the deviation index of tumor cells and the side effect was also correlated with the deviation index of liver cells. This method could predict the effectiveness of carcinostatic agent especially short acting cytocidal drugs. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.34.4.315 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/344/344.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 34, 号 4, p. 315-333, 発行日 1972-03 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/18708 | |||||
識別子タイプ | HDL |