@article{oai:nagoya.repo.nii.ac.jp:00016711,
 author = {HIRABAYASHI, NORIO},
 issue = {2-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {Based on the concept that the lymph node is composed of four functionally distinct compartments, popliteal lymph nodes of three week-old rats were studied histologically after a single primary antigenic stimulation. A variety of antigens, i.e., SRBC, pertussis vaccine, bovine γ-globulin, crystalline bacterial amylase, egg albumin, diphtheria toxoid with or without the adjuvant always producerl a consistent pattern of development and involution sequentially in each of four compartments: the paracortical areas were always the first in making response, followed primary follicles, medullary cords and germinal centers in this order. The mitotic indices in the paracortical areas reached the maximum on the third day whereas the peak activity of the germinal centers was observed between the 1Oth to 24th day. The development of germinal centers which had not been observed until the late stage might reflect its probable role in the development of immunological memory. The role of paracortical areas in the initiation of "true" primary response was discussed in the light of current theories on the cell-to-cell interaction as well as the relationship between humoral and cell-mediated immune response. This led to postulation that the paracortical hyperplasia was essential for the induction of primary immune response, especially in "true" primary response.},
 pages = {157--174},
 title = {Dynamics of Cell Populations in Lymph Node During Primary Immune Response},
 volume = {35},
 year = {1973}
}