ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "a77401fb-b968-4cfd-88d6-4e9b3bffcb97"}, "_deposit": {"id": "16717", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16717"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00016717", "sets": ["1508"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1968-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "505", "bibliographicPageStart": "491", "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Although extensive studies on the anemia and iron metabolism in patients with malignant neoplasms have been made, the pathogenesis of the anemia observed in cancer patients remains obscure. The first purpose of this paper is to elucidate the functional impairment in red cell production in patients with malignant neoplasm by means of ferrokinetic studies. The second one is to clarify how the reticulo-endothelial cells participate in alterations of iron metabolism in malignancy by means of 59Fe labeled iron-dextran. The third one is to enumerate sideroblasts in bone marrow smears of cancer patients for assessing stainable iron in erythroblasts. The results obtained were as follows: 1) Ferrokinetic studies with 59Fe-citrate showed the increased rate of erythropoiesis in patients with malignant neoplasm. However, studies on cases with infections gave results very similar to those in malignant neoplasms, suggesting the· existence of a mechanism common in both conditions. 2) The studies with 59Fe labeled iron-dextran revealed a significant decrease of utilization of radioiron for hemoglobin synthesis from iron-dextran captured in reticulo-endothelial cells in malignant diseases. 3) The percentage of bone marrow sideroblasts in patients with malignant neoplasms showed a significant decrease with the mean value of 28 percent. The evidences obtained above demonstrated that the erythropoietic activity in patients with malignant neoplasms is maintained above normal, while there is an evident impairment of iron release from reticulo-endothelial cells. However, the mechanism responsible for the defect of iron release in malignancy is not clear and required further study.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.30.4.491", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "異版である", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/304/304.html ", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN(Online)", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "YAMADA, HIDEO"}], "nameIdentifiers": [{"nameIdentifier": "96201", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v30n4p491_505.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "v30n4p491_505.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/16717/files/v30n4p491_505.pdf"}, "version_id": "3b5ed0c0-fae3-4e64-a3c9-ec998c32191b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies"}]}, "item_type_id": "9", "owner": "1", "path": ["1508"], "permalink_uri": "https://doi.org/10.18999/nagjms.30.4.491", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-22"}, "publish_date": "2013-10-22", "publish_status": "0", "recid": "16717", "relation": {}, "relation_version_is_last": true, "title": ["Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies"], "weko_shared_id": null}
  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 30(4)

Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies

https://doi.org/10.18999/nagjms.30.4.491
https://doi.org/10.18999/nagjms.30.4.491
7ca6d68b-7059-479d-a2b4-fe6f5eac21e2
名前 / ファイル ライセンス アクション
v30n4p491_505.pdf v30n4p491_505.pdf (1.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-22
タイトル
タイトル Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies
著者 YAMADA, HIDEO

× YAMADA, HIDEO

WEKO 96201

YAMADA, HIDEO

Search repository
抄録
内容記述 Although extensive studies on the anemia and iron metabolism in patients with malignant neoplasms have been made, the pathogenesis of the anemia observed in cancer patients remains obscure. The first purpose of this paper is to elucidate the functional impairment in red cell production in patients with malignant neoplasm by means of ferrokinetic studies. The second one is to clarify how the reticulo-endothelial cells participate in alterations of iron metabolism in malignancy by means of 59Fe labeled iron-dextran. The third one is to enumerate sideroblasts in bone marrow smears of cancer patients for assessing stainable iron in erythroblasts. The results obtained were as follows: 1) Ferrokinetic studies with 59Fe-citrate showed the increased rate of erythropoiesis in patients with malignant neoplasm. However, studies on cases with infections gave results very similar to those in malignant neoplasms, suggesting the· existence of a mechanism common in both conditions. 2) The studies with 59Fe labeled iron-dextran revealed a significant decrease of utilization of radioiron for hemoglobin synthesis from iron-dextran captured in reticulo-endothelial cells in malignant diseases. 3) The percentage of bone marrow sideroblasts in patients with malignant neoplasms showed a significant decrease with the mean value of 28 percent. The evidences obtained above demonstrated that the erythropoietic activity in patients with malignant neoplasms is maintained above normal, while there is an evident impairment of iron release from reticulo-endothelial cells. However, the mechanism responsible for the defect of iron release in malignancy is not clear and required further study.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.30.4.491
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/304/304.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 30, 号 4, p. 491-505, 発行日 1968-03
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 09:37:05.576516
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3