{"_buckets": {"deposit": "a77401fb-b968-4cfd-88d6-4e9b3bffcb97"}, "_deposit": {"id": "16717", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16717"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00016717", "sets": ["1508"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1968-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "505", "bibliographicPageStart": "491", "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Although extensive studies on the anemia and iron metabolism in patients with malignant neoplasms have been made, the pathogenesis of the anemia observed in cancer patients remains obscure. The first purpose of this paper is to elucidate the functional impairment in red cell production in patients with malignant neoplasm by means of ferrokinetic studies. The second one is to clarify how the reticulo-endothelial cells participate in alterations of iron metabolism in malignancy by means of 59Fe labeled iron-dextran. The third one is to enumerate sideroblasts in bone marrow smears of cancer patients for assessing stainable iron in erythroblasts. The results obtained were as follows: 1) Ferrokinetic studies with 59Fe-citrate showed the increased rate of erythropoiesis in patients with malignant neoplasm. However, studies on cases with infections gave results very similar to those in malignant neoplasms, suggesting the· existence of a mechanism common in both conditions. 2) The studies with 59Fe labeled iron-dextran revealed a significant decrease of utilization of radioiron for hemoglobin synthesis from iron-dextran captured in reticulo-endothelial cells in malignant diseases. 3) The percentage of bone marrow sideroblasts in patients with malignant neoplasms showed a significant decrease with the mean value of 28 percent. The evidences obtained above demonstrated that the erythropoietic activity in patients with malignant neoplasms is maintained above normal, while there is an evident impairment of iron release from reticulo-endothelial cells. However, the mechanism responsible for the defect of iron release in malignancy is not clear and required further study.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.30.4.491", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "異版である", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/304/304.html ", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN（Online）", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "YAMADA, HIDEO"}], "nameIdentifiers": [{"nameIdentifier": "96201", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v30n4p491_505.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "v30n4p491_505.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/16717/files/v30n4p491_505.pdf"}, "version_id": "3b5ed0c0-fae3-4e64-a3c9-ec998c32191b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies"}]}, "item_type_id": "9", "owner": "1", "path": ["1508"], "permalink_uri": "https://doi.org/10.18999/nagjms.30.4.491", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-22"}, "publish_date": "2013-10-22", "publish_status": "0", "recid": "16717", "relation": {}, "relation_version_is_last": true, "title": ["Clinical Studies on Iron Kinetics : II. Iron Kinetics Studies in Patients with Malignant Neoplasms : with Special Reference to Ferrokinetics and 59Fe Labeled Iron-Dextran Studies"], "weko_shared_id": null}