@phdthesis{oai:nagoya.repo.nii.ac.jp:00016792,
 author = {Matsudaira, Kyoko and Maeda, Kengo and Okumura, Naoki and Yoshikawa, Daiji and Morita, Yasuhiro and Mitsuhashi, Hirotsugu and Ishii, Hideki and Kondo, Takahisa and Murohara, Toyoaki and on, behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group},
 month = {Mar},
 note = {Background: Vascular endothelial growth factor (VEGF) is induced by myocardial ischemia and is thought to facilitate cardiovascular repair after acute myocardial infarction (AMI). However, the association between the plasma VEGF levels and clinical outcome in AMI patients is unclear. Methods and Results: We evaluated 879 AMI patients undergoing successful primary revascularization within 24h of symptom onset. The patients were classified into 3 groups according to tertiles of plasma VEGF levels at 7 days after the onset of AMI. Major adverse cardiovascular and cerebrovascular events (MACCE), defined as cardiac death, recurrent acute coronary syndrome, hospital readmission for heart failure, or stroke, were assessed during the 6-month follow-up period. The incidence of MACCE was the least frequent in the middle tertile. Compared to the middle tertile, patients in the low tertile were at a significantly higher risk for MACCE even after adjusting for baseline characteristics (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.18-6.06, P=0.019). An absence of statin treatment before onset and a younger age (HR 0.54, 0.87; 95%CI 0.33-0.90, 0.76-0.99; P=0.017, 0.037; respectively) were significantly associated with low VEGF. Conclusions: Low plasma VEGF levels at 7 days after the onset of AMI were associated with a significantly increased risk for MACCE during 6 months of follow-up., 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 松平京子氏の博士論文として提出された},
 school = {名古屋大学, Nagoya University},
 title = {Impact of Low Levels of Vascular Endothelial Growth Factor After Myocardial Infarction on 6-Month Clinical Outcome : Results From the Nagoya Acute Myocardial Infarction Study},
 year = {2012}
}