{"_buckets": {"deposit": "be9c057a-d5fc-4cb9-8b62-cb847f2d10b3"}, "_deposit": {"id": "16870", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16870"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00016870", "sets": ["1165"]}, "author_link": ["50183", "50184", "50185", "50186", "50187", "50188", "50189"], "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "1181", "bibliographicPageStart": "1171", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "Cytotherapy", "bibliographic_titleLang": "en"}]}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2012-09-01"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Nagoya University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background aims. Mesenchymal stromal cells (MSC) can be isolated from the perivascular connective tissue of umbilical cords, called Wharton\u0027s jelly. These human umbilical cord perivascular cells (HUCPVC) might provide therapeutic benefits when treating skeletal or cutaneous malformations in neonatal patients. Methods. HUCPVC were isolated, and their proliferation rate, marker expression and multilineage differentiation potential determined. HUCPVC or their conditioned medium (HUCPVC-CM) was injected into the excisional wound of a mouse splinted-wound model. The effects of the treatment on wound closure were examined by morphohistochemical and gene expression analyses. Results. HUCPVC expressed typical MSC markers and could differentiate into osteoblastic and adipogenic lineages. HUCPVC transplanted into the mouse wound accelerated wound closure. Immunohistologic analysis showed that the HUCPVC accelerated wound healing by enhancing collagen deposition and angiogenesis via paracrine mechanisms. Furthermore, treatment with HUCPVC-CM alone significantly enhanced wound closure. HUCPVC-CM increased the number of anti-inflammatory M2 macrophages expressing resistin-like molecule (RELM)-α/CD11b and promoted neovessel maturation. Quantitative polymerase chain reaction (PCR) analysis showed that HUCPVC-CM increased the expression of tissue-repairing cytokines interleukin (IL)-10, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF)-1 and angiopoietin-1 at the healing wound. Conclusions. Our results show that HUCPVC promotes wound healing via multifaceted paracrine mechanisms. Together with their ability to differentiate into the osteogenic linage, HUCPVC may provide significant therapeutic benefits for treating wounds in neonatal patients.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年1月31日 匠原龍太郎氏の博士論文として提出された", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第9936号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.3109/14653249.2012.706705"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/18891"}]}, "item_12_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Informa healthcare", "subitem_publisher_language": "en"}]}, "item_12_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3109/14653249.2012.706705", "subitem_relation_type_select": "DOI"}}]}, "item_12_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the author\u0027s version of a work that was accepted for publication in Cytotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cytotherapy. v.14, n.10, 2012, p.1171-1181 DOI: 10.3109/14653249.2012.706705", "subitem_rights_language": "en"}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1465-3249", "subitem_source_identifier_type": "PISSN"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2012"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shohara, Ryutaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50183", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Akihito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50184", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takikawa, Sachiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50185", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwase, Akira", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50186", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hibi, Hideharu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50187", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikkawa, Fumitaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50188", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Minoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "50189", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k9936_thesis.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "k9936_thesis.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/16870/files/k9936_thesis.pdf"}, "version_id": "e290c87d-7ea7-4cde-bb4c-cb95a1d63196"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "human umbilical cord perivascular cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "wound healing", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mesenchymal stromal cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-inflammatory M2 macrophage", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Mesenchymal stromal cells of human umbilical cord Wharton\u0027s jelly accelerate wound healing by paracrine mechanisms", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Mesenchymal stromal cells of human umbilical cord Wharton\u0027s jelly accelerate wound healing by paracrine mechanisms", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "1", "path": ["1165"], "permalink_uri": "http://hdl.handle.net/2237/18891", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-11-15"}, "publish_date": "2013-11-15", "publish_status": "0", "recid": "16870", "relation": {}, "relation_version_is_last": true, "title": ["Mesenchymal stromal cells of human umbilical cord Wharton\u0027s jelly accelerate wound healing by paracrine mechanisms"], "weko_shared_id": -1}