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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms

http://hdl.handle.net/2237/18891
http://hdl.handle.net/2237/18891
7968e696-05a2-40c9-bcb4-397b319be56b
名前 / ファイル ライセンス アクション
k9936_thesis.pdf k9936_thesis.pdf (1.4 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-11-15
タイトル
タイトル Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms
言語 en
著者 Shohara, Ryutaro

× Shohara, Ryutaro

WEKO 50183

en Shohara, Ryutaro

Search repository
Yamamoto, Akihito

× Yamamoto, Akihito

WEKO 50184

en Yamamoto, Akihito

Search repository
Takikawa, Sachiko

× Takikawa, Sachiko

WEKO 50185

en Takikawa, Sachiko

Search repository
Iwase, Akira

× Iwase, Akira

WEKO 50186

en Iwase, Akira

Search repository
Hibi, Hideharu

× Hibi, Hideharu

WEKO 50187

en Hibi, Hideharu

Search repository
Kikkawa, Fumitaka

× Kikkawa, Fumitaka

WEKO 50188

en Kikkawa, Fumitaka

Search repository
Ueda, Minoru

× Ueda, Minoru

WEKO 50189

en Ueda, Minoru

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author's version of a work that was accepted for publication in Cytotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cytotherapy. v.14, n.10, 2012, p.1171-1181 DOI: 10.3109/14653249.2012.706705
キーワード
主題Scheme Other
主題 human umbilical cord perivascular cells
キーワード
主題Scheme Other
主題 wound healing
キーワード
主題Scheme Other
主題 mesenchymal stromal cells
キーワード
主題Scheme Other
主題 anti-inflammatory M2 macrophage
抄録
内容記述 Background aims. Mesenchymal stromal cells (MSC) can be isolated from the perivascular connective tissue of umbilical cords, called Wharton's jelly. These human umbilical cord perivascular cells (HUCPVC) might provide therapeutic benefits when treating skeletal or cutaneous malformations in neonatal patients. Methods. HUCPVC were isolated, and their proliferation rate, marker expression and multilineage differentiation potential determined. HUCPVC or their conditioned medium (HUCPVC-CM) was injected into the excisional wound of a mouse splinted-wound model. The effects of the treatment on wound closure were examined by morphohistochemical and gene expression analyses. Results. HUCPVC expressed typical MSC markers and could differentiate into osteoblastic and adipogenic lineages. HUCPVC transplanted into the mouse wound accelerated wound closure. Immunohistologic analysis showed that the HUCPVC accelerated wound healing by enhancing collagen deposition and angiogenesis via paracrine mechanisms. Furthermore, treatment with HUCPVC-CM alone significantly enhanced wound closure. HUCPVC-CM increased the number of anti-inflammatory M2 macrophages expressing resistin-like molecule (RELM)-α/CD11b and promoted neovessel maturation. Quantitative polymerase chain reaction (PCR) analysis showed that HUCPVC-CM increased the expression of tissue-repairing cytokines interleukin (IL)-10, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF)-1 and angiopoietin-1 at the healing wound. Conclusions. Our results show that HUCPVC promotes wound healing via multifaceted paracrine mechanisms. Together with their ability to differentiate into the osteogenic linage, HUCPVC may provide significant therapeutic benefits for treating wounds in neonatal patients.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年1月31日 匠原龍太郎氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Informa healthcare
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3109/14653249.2012.706705
ISSN
収録物識別子タイプ PISSN
収録物識別子 1465-3249
書誌情報 en : Cytotherapy

巻 14, 号 10, p. 1171-1181, 発行日 2012-09
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 Nagoya University
学位授与年度
学位授与年度 2012
学位授与年月日
学位授与年月日 2012-09-01
学位授与番号
学位授与番号 甲第9936号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.3109/14653249.2012.706705
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/18891
識別子タイプ HDL
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