{"created":"2021-03-01T06:24:43.778224+00:00","id":17399,"links":{},"metadata":{"_buckets":{"deposit":"3a442818-9adb-434c-97c9-82341ba6ed67"},"_deposit":{"created_by":17,"id":"17399","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"17399"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00017399","sets":["499:508:509:1563"]},"author_link":["51109","51110","51111","51112","51113","51114","51115","51116","51117"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"49","bibliographicPageStart":"35","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.ZLepr fa/Lepr fa (DS/obese) rats, which we recently established as a new animal model of metabolic syndrome. The heart of DS/obese rats was compared with that of homozygous lean littermates (DahlS.Z-Lepr+/Lepr+, or DS/lean, rats). DS/obese rats manifested hypertension as well as left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 18 weeks of age. Myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Telomere length in myocardial cells did not differ between the two rat strains, whereas telomerase activity and expression of the telomerase reverse transcriptase gene were increased in DS/obese rats. Expression of the senescence-associated genes for checkpoint kinase 2 (Chk2), p53, and p21 as well as that of genes related to the renin-angiotensin-aldosterone system were also up-regulated in the DS/obese rat heart. Our results indicate that DS/obese rats undergo premature cardiac senescence as well as cardiac remodeling in association with the development of diastolic dysfunction in these animals.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/19482"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.76.1-2.35","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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YUURI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WATANABE, SHOGO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MUROHARA, TOYOAKI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAGATA, KOHZO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51117","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-21"}],"displaytype":"detail","filename":"05_Takahashi.pdf","filesize":[{"value":"570.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"05_Takahashi.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/17399/files/05_Takahashi.pdf"},"version_id":"47a01742-e883-4eb2-8509-c73e63fe538b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"metabolic syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiac remodeling","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"renin-angiotensin-aldosterone system","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiac senescence","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1563"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-03"},"publish_date":"2014-03-03","publish_status":"0","recid":"17399","relation_version_is_last":true,"title":["Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:32:03.808685+00:00"}