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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 76(1-2)

Glucocorticoids Activate Cardiac Mineralocorticoid Receptors in Adrenalectomized Dahl Salt- Sensitive Rats

https://doi.org/10.18999/nagjms.76.1-2.59
https://doi.org/10.18999/nagjms.76.1-2.59
aa96392e-9a75-43d4-80da-82c1e73041dc
名前 / ファイル ライセンス アクション
07_Ohtake.pdf 07_Ohtake.pdf (1.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-03
タイトル
タイトル Glucocorticoids Activate Cardiac Mineralocorticoid Receptors in Adrenalectomized Dahl Salt- Sensitive Rats
著者 OHTAKE, MASAFUMI

× OHTAKE, MASAFUMI

WEKO 51119

OHTAKE, MASAFUMI

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HATTORI, TAKUYA

× HATTORI, TAKUYA

WEKO 51120

HATTORI, TAKUYA

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MURASE, TAMAYO

× MURASE, TAMAYO

WEKO 51121

MURASE, TAMAYO

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TAKAHASHI, KEIJI

× TAKAHASHI, KEIJI

WEKO 51122

TAKAHASHI, KEIJI

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TAKATSU, MIWA

× TAKATSU, MIWA

WEKO 51123

TAKATSU, MIWA

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OHTAKE, MAYUKO

× OHTAKE, MAYUKO

WEKO 51124

OHTAKE, MAYUKO

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MIYACHI, MASAAKI

× MIYACHI, MASAAKI

WEKO 51125

MIYACHI, MASAAKI

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WATANABE, SHOGO

× WATANABE, SHOGO

WEKO 51126

WATANABE, SHOGO

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CHENG, XIAN WU

× CHENG, XIAN WU

WEKO 51127

CHENG, XIAN WU

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MUROHARA, TOYOAKI

× MUROHARA, TOYOAKI

WEKO 51128

MUROHARA, TOYOAKI

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NAGATA, KOHZO

× NAGATA, KOHZO

WEKO 51129

NAGATA, KOHZO

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キーワード
主題Scheme Other
主題 glucocorticoids
キーワード
主題Scheme Other
主題 mineralocorticoid receptor
キーワード
主題Scheme Other
主題 diastolic function
キーワード
主題Scheme Other
主題 oxidative stress
キーワード
主題Scheme Other
主題 inflammation
抄録
内容記述 We previously showed that selective mineralocorticoid receptor (MR) blockade by eplerenone is cardioprotective in Dahl salt-sensitive (DS) rats. To clarify the consequences of glucocorticoid-mediated MR activation in these animals, we investigated the effects of exogenous corticosterone on blood pressure as well as cardiac remodeling and function after adrenalectomy. DS rats were subjected to adrenalectomy at 6 weeks of age and thereafter fed a high-salt diet and administered corticosterone (20 mg/kg per day) or vehicle. Systolic blood pressure was higher in the corticosterone group than in the vehicle group at 7 weeks and thereafter. By 11 weeks, corticosterone had reduced left ventricular (LV) mass and induced LV diastolic dysfunction. The ratio of collagen type I to type III mRNA levels in the left ventricle was increased in the corticosterone group compared with the vehicle group. Administration of a non-antihypertensive dose of the MR antagonist spironolactone (20 mg/kg per day) from 6 weeks inhibited the effects of corticosterone on both the collagen type I to type III mRNA ratio and diastolic function without affecting the decrease in LV mass. Spironolactone attenuated both the increase in NADPH oxidase activity in the left ventricle and coronary vascular inflammatory responses apparent in the corticosterone group. These results indicate that exogenous glucocorticoids induce hypertension, cardiac remodeling, and diastolic dysfunction in adrenalectomized DS rats fed a high-salt diet. The cardiac effects of exogenous glucocorticoids are likely attributable, at least in part, to myocardial oxidative stress and coronary vascular inflammation induced by glucocorticoid-activated MRs..
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.76.1-2.59
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 76, 号 1-2, p. 59-72, 発行日 2014-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/19484
識別子タイプ HDL
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