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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 76(1-2)

A Novel Method for Managing Water and Electrolyte Balance after Transsphenoidal Surgery: Preliminary Study of Moderate Water Intake Restriction

https://doi.org/10.18999/nagjms.76.1-2.73
https://doi.org/10.18999/nagjms.76.1-2.73
0780a84e-ef92-49d7-ad38-9b722be2f2b5
名前 / ファイル ライセンス アクション
08_Takeuchi.pdf 08_Takeuchi.pdf (307.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-03
タイトル
タイトル A Novel Method for Managing Water and Electrolyte Balance after Transsphenoidal Surgery: Preliminary Study of Moderate Water Intake Restriction
著者 TAKEUCHI, KAZUHITO

× TAKEUCHI, KAZUHITO

WEKO 51130

TAKEUCHI, KAZUHITO

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NAGATANI, TETSUYA

× NAGATANI, TETSUYA

WEKO 51131

NAGATANI, TETSUYA

Search repository
OKUMURA, ERIKO

× OKUMURA, ERIKO

WEKO 51132

OKUMURA, ERIKO

Search repository
WAKABAYASHI, TOSHIHIKO

× WAKABAYASHI, TOSHIHIKO

WEKO 51133

WAKABAYASHI, TOSHIHIKO

Search repository
キーワード
主題Scheme Other
主題 Hyponatremia
キーワード
主題Scheme Other
主題 Transsphenoidal Surgery
キーワード
主題Scheme Other
主題 Pituitary Tumor
キーワード
主題Scheme Other
主題 Syndrome of Inappropriate
キーワード
主題Scheme Other
主題 Secretion of Antidiuretic Hormone
キーワード
主題Scheme Other
主題 Thirst
抄録
内容記述 Hyponatremia is a common and potentially serious complication of transsphenoidal surgery (TSS). Since September 2009, we have implemented moderate water intake restriction (<2500 mL/day) after TSS in an attempt to prevent this complication. The aim of this study was to investigate the efficacy of a combination of moderate restriction of water intake plus antidiuretic hormone (arginine vasopressin [AVP]) replacement therapy in patients with diabetes insipidus (DI) for reducing the incidence of delayed hyponatremia after TSS. Patients treated from September 2005 to August 2009 were allowed to drink water freely after surgery (the control group), while patients treated from September 2009 to June 2012 were restricted to less than 2500 mL water per day (the water restriction group). To reduce the occurrence of hypernatremia, AVP replacement therapy was provided immediately after the development of DI. We retrospectively analyzed the incidence of hyponatremia, DI, and hypernatremia in patients following TSS. Hyponatremia incidence was significantly lower in the water restriction group (P = 0.017); however, there were no significant differences in DI incidence and hypernatremia incidence between the 2 groups. Under DI control with AVP replacement therapy, the water restriction group showed no significant difference in the daily self-rated thirst level for the patients with and without DI. Moderate water intake restriction in addition to AVP replacement therapy significantly decreases the incidence of hyponatremia without patient discomfort (extreme thirst) and other complications. However, further studies are required to determine the most effective amount of water and the optimal duration of postoperative water restriction.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.76.1-2.73
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 76, 号 1-2, p. 73-82, 発行日 2014-02
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/19485
識別子タイプ HDL
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