{"created":"2021-03-01T06:24:44.231715+00:00","id":17406,"links":{},"metadata":{"_buckets":{"deposit":"0ab4638e-2844-4d69-9183-d375618716e1"},"_deposit":{"created_by":17,"id":"17406","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"17406"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00017406","sets":["499:508:509:1563"]},"author_link":["51150","51151","51152","51153"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"120","bibliographicPageStart":"113","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that regulates the expression of antioxidant genes by activating Nrf2-antioxidant response element (ARE) pathway. This study aimed to investigate association of Nrf2 gene single nucleotide polymorphisms (SNPs), rs35652124 (A→G) and rs6721961 (C→A), with various laboratory data in 464 health evaluation examinees. The genotyping of these SNPs was performed using polymerase chain reaction with confronting two-pair primers (PCR-CTPP) assay. The genotype frequencies of rs35652124 SNP were 21.1% for AA, 44.0% for AG, and 34.9% for GG. The frequency of A allele was 0.431. In male subjects, cholinesterase was significantly high, and HDL cholesterol was significantly low in (AG+GG) carriers. In female subjects, diastolic blood pressure (BP) was significantly low in (AG+GG) carriers. The genotype frequencies of rs6721961 SNP were 55.2% for CC, 34.7% for CA, and 10.1% for AA. The frequency of A allele was 0.275. In male subjects, systolic BP, diastolic BP and cholinesterase were significantly low, and iron was significantly high in (CA+AA) carriers. In female subjects, cholinesterase was significantly high in (CA+AA) carriers, and diastolic BP was significantly high in AA carriers. In conclusion, Nrf2 polymorphisms are associated with BP in Japanese.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/19489"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.76.1-2.113","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SHIMOYAMA, YASUHIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MITSUDA, YOKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAMAJIMA, NOBUYUKI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NIWA, TOSHIMITSU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"51153","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-21"}],"displaytype":"detail","filename":"12_Shimoyama.pdf","filesize":[{"value":"184.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"12_Shimoyama.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/17406/files/12_Shimoyama.pdf"},"version_id":"dafed630-05f2-485d-97ff-0ba3f5b0c615"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nrf2","subitem_subject_scheme":"Other"},{"subitem_subject":"blood pressure","subitem_subject_scheme":"Other"},{"subitem_subject":"SNP","subitem_subject_scheme":"Other"},{"subitem_subject":"cholinesterase","subitem_subject_scheme":"Other"},{"subitem_subject":"HDL cholesterol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Polymorphisms of Nrf2, an Antioxidative Gene, are Associated with Blood Pressure in Japanese","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Polymorphisms of Nrf2, an Antioxidative Gene, are Associated with Blood Pressure in Japanese","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1563"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-04"},"publish_date":"2014-03-04","publish_status":"0","recid":"17406","relation_version_is_last":true,"title":["Polymorphisms of Nrf2, an Antioxidative Gene, are Associated with Blood Pressure in Japanese"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:19:39.291959+00:00"}