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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 76(1-2)

Biochemical Staging of the Chronic Hepatic Lesions of Wilson Disease

https://doi.org/10.18999/nagjms.76.1-2.139
https://doi.org/10.18999/nagjms.76.1-2.139
d861f013-e835-44df-bb9f-e59acc213eff
名前 / ファイル ライセンス アクション
15_Katano.pdf 15_Katano.pdf (365.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-04
タイトル
タイトル Biochemical Staging of the Chronic Hepatic Lesions of Wilson Disease
著者 KATANO, YOSHIAKI

× KATANO, YOSHIAKI

WEKO 51164

KATANO, YOSHIAKI

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HAYASHI, KAZUHIKO

× HAYASHI, KAZUHIKO

WEKO 51165

HAYASHI, KAZUHIKO

Search repository
HATTORI, AI

× HATTORI, AI

WEKO 51166

HATTORI, AI

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TATSUMI, YASUAKI

× TATSUMI, YASUAKI

WEKO 51167

TATSUMI, YASUAKI

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UEYAMA, JUN

× UEYAMA, JUN

WEKO 51168

UEYAMA, JUN

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WAKUSAWA, SHINYA

× WAKUSAWA, SHINYA

WEKO 51169

WAKUSAWA, SHINYA

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YANO, MOTOYOSHI

× YANO, MOTOYOSHI

WEKO 51170

YANO, MOTOYOSHI

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TOYODA, HIDENORI

× TOYODA, HIDENORI

WEKO 51171

TOYODA, HIDENORI

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KUMADA, TAKASHI

× KUMADA, TAKASHI

WEKO 51172

KUMADA, TAKASHI

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MIZUTANI, NAOKI

× MIZUTANI, NAOKI

WEKO 51173

MIZUTANI, NAOKI

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HAYASHI, HISAO

× HAYASHI, HISAO

WEKO 51174

HAYASHI, HISAO

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GOTO, HIDEMI

× GOTO, HIDEMI

WEKO 51175

GOTO, HIDEMI

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キーワード
主題Scheme Other
主題 AST
キーワード
主題Scheme Other
主題 ALT
キーワード
主題Scheme Other
主題 Phenotype
キーワード
主題Scheme Other
主題 Stage
キーワード
主題Scheme Other
主題 Wilson disease
抄録
内容記述 Background: Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history of Wilson disease. Phenotypes were simplified into hepatic, acute, and neurologic. The bio-low stage of both enzymes was less than 40 IU/L, the bio-moderate stage was intermediate between 40 and 200 IU/L, and the bio-high stage was more than 200 IU/L of either or both enzymes. Rebounded enzyme levels at the recovery period from anemia were presumed to be the chronic baselines when pre-anemic enzyme levels were not available in the acute phenotype. We investigated whether these enzyme levels may provide information useful for screening patients. The natural history of chronic Wilson disease consisted of the first increasing and second decreasing phases. The clinical courses of a 4-year-old boy and 12-year-old girl were representative of the 2 phases, respectively. All but one patient were in the decreasing phase. Negative correlations were obtained between age and enzyme level in the decreasing phase. The hepatic phenotype may be a prototype found throughout the 2 phases, and acute and neurologic phenotypes may be major complications in the bio-moderate and bio-low stages of the decreasing phase, respectively. Biochemical staging may provide a better understanding of Wilson disease when combined with phenotypes. Bio-high stage patients should be referred to a medical center for diagnosis.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.76.1-2.139
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 76, 号 1-2, p. 139-148, 発行日 2014-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/19492
識別子タイプ HDL
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