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外部基準にシクロヘキサンを用いた1Hスペクトロスコピーの定量化
http://hdl.handle.net/2237/19564
http://hdl.handle.net/2237/1956424365b0b-0c4b-416f-a83d-f5fcdaf38bef
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-03-11 | |||||
タイトル | ||||||
タイトル | 外部基準にシクロヘキサンを用いた1Hスペクトロスコピーの定量化 | |||||
言語 | ja | |||||
その他のタイトル | ||||||
その他のタイトル | Quantification of Brain Metabolites by 1H Spectroscopy Using Cyclohexane as an External Reference | |||||
言語 | en | |||||
著者 |
前田, 尚利
× 前田, 尚利× 滝, 一郎× 安藤, 容子× 松島, 秀× Maeda, Hisatoshi× Taki, Ichirou× Ando, Yoko× Matsushima, Shigeru |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MR spectroscopy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Quantification | |||||
抄録 | ||||||
内容記述 | We tested the reliability of quantifying brain metabolite concentrations by MR spectroscopy. We employed a PRESS sequence and used a cyclohexane sample as an external standard. The signal intensity ratios of water and cyclohexane were measured by changing the geometrical arrangement of the cyclohexane sample and water phantom with various loading factors of the coil. Choline (Cho) concentrations were calculated from the signal intensity ratios of Cho and water and compared with actual Cho concentrations (1.0 to 2.6 mmol/L). The brain metabolites Cho, creatine/phosphocreatine (Cr/PCr) and N-acetylaspartate (NAA) were evaluated in five normal volunteers and six patients with metastatic brain cancer before (0 Gy), after 20 Gy and after 40 Gy of whole brain radiotherapy. Variation in the ratio of spectrum intensity between water and cyclohexane was less than 1.5% for various geometrical arrangements and loading factors. The error in quantification of Cho concentrations in the phantom study was 0.05 +/- 0.10 mmol/L. The concentrations measured in the volunteers were: Cho 1.6 +/- 0.4 mmol/L, Cr/PCr 6.4 +/- 1.1 mmol/L and NAA 8.2 +/- 0.1 mmol/L. There was no significant difference (p > 0.05) in these concentrations between the control group and the patients before, during, or after radiotherapy. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 日本医学放射線学会 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0048-0428 | |||||
書誌情報 |
ja : 日本医学放射線学会雑誌 巻 56, 号 8, p. 579-587, 発行日 1996-07-25 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/19564 | |||||
識別子タイプ | HDL |