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アイテム
高果糖食負荷ラットでのインスリン作用に対するアロプリノールの影響
https://doi.org/10.18999/njhpfs.35.1.23
https://doi.org/10.18999/njhpfs.35.1.2342d72886-f52e-44f8-b39a-b6049c5a8999
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
4_No35-1.pdf (940.0 kB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-11 | |||||
| タイトル | ||||||
| タイトル | 高果糖食負荷ラットでのインスリン作用に対するアロプリノールの影響 | |||||
| 言語 | ja | |||||
| その他のタイトル | ||||||
| その他のタイトル | Effects of allopurinol on insulin action in fructose-fed rats | |||||
| 著者 |
姜, 海英
× 姜, 海英× 小池, 晃彦× 木, 蘭× 夏目, 有紀枝× 王, 忠華× 成, 憲武× 押田, 芳治× Jiang, Haiying× Koike, Teruhiko× Mu, Lan× Natsume, Yukie× Wang, Zhonghua× Cheng, Xianwu× Oshida, Yoshiharu |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To investigate how allopurinol (a xanthine oxidase inhibitor) improves insulin action of rats fed with high-fructose diet. Methods: Male Wistar rats were randomly divided into 3 groups and each group was fed one of the following diets for 4 weeks: standard chow diet, high-fructose diet, and high-fructose diet plus allopurinol. A part of rats in the high-fructose diet plus allopurinol group were infused with a NOS inhibitor, NG-monomethyl-Larginine (L-NMMA), during the euglycemic clamp studies (insulin infusion rate: 3.0mU/kg/min). Insulin sensitivity index was assessed from the oral glucose tolerance test (OGTT). Results: Serum uric acid and plasma insulin concentrations were significantly decreased with allopurinol treatment. High-fructose feeding produced a marked decrease in insulin sensitivity index compared with standard chow diet feeding. Allopurinol treated high-fructose fed rats showed a significant increase in insulin sensitivity index, reaching a similar level as that of the standard chow diet feeding. Infusion of L-NMMA did not change the glucose infusion rate of high-fructose fed rats with allopurinol in the euglycemic clamp. Conclusion: Improvement of insulin action with allopurinol in fructose-fed rats may not be associated with increase in production of nitric oxide. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 名古屋大学総合保健体育科学センター | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/njhpfs.35.1.23 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0289-5412 | |||||
| 書誌情報 |
ja : 総合保健体育科学 巻 35, 号 1, p. 23-27, 発行日 2012-03-30 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/20222 | |||||
| 識別子タイプ | HDL | |||||
