@article{oai:nagoya.repo.nii.ac.jp:00018216,
 author = {姜, 海英 and 小池, 晃彦 and 木, 蘭 and 夏目, 有紀枝 and 王, 忠華 and 成, 憲武 and 押田, 芳治 and Jiang, Haiying and Koike, Teruhiko and Mu, Lan and Natsume, Yukie and Wang, Zhonghua and Cheng, Xianwu and Oshida, Yoshiharu},
 issue = {1},
 journal = {総合保健体育科学},
 month = {Mar},
 note = {Objective: To investigate how allopurinol (a xanthine oxidase inhibitor) improves insulin action of rats fed with high-fructose diet. Methods: Male Wistar rats were randomly divided into 3 groups and each group was fed one of the following diets for 4 weeks: standard chow diet, high-fructose diet, and high-fructose diet plus allopurinol. A part of rats in the high-fructose diet plus allopurinol group were infused with a NOS inhibitor, NG-monomethyl-Larginine (L-NMMA), during the euglycemic clamp studies (insulin infusion rate: 3.0mU/kg/min). Insulin sensitivity index was assessed from the oral glucose tolerance test (OGTT). Results: Serum uric acid and plasma insulin concentrations were significantly decreased with allopurinol treatment. High-fructose feeding produced a marked decrease in insulin sensitivity index compared with standard chow diet feeding. Allopurinol treated high-fructose fed rats showed a significant increase in insulin sensitivity index, reaching a similar level as that of the standard chow diet feeding. Infusion of L-NMMA did not change the glucose infusion rate of high-fructose fed rats with allopurinol in the euglycemic clamp. Conclusion: Improvement of insulin action with allopurinol in fructose-fed rats may not be associated with increase in production of nitric oxide.},
 pages = {23--27},
 title = {高果糖食負荷ラットでのインスリン作用に対するアロプリノールの影響},
 volume = {35},
 year = {2012}
}