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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Cooperativity, connectivity, and folding pathways of multidomain proteins

http://hdl.handle.net/2237/20615
6efeef9f-d9e0-47b7-b342-4eb366593e4a
名前 / ファイル ライセンス アクション
PNAS-2008-Itoh-13865-70.pdf PNAS-2008-Itoh-13865-70.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-30
タイトル
タイトル Cooperativity, connectivity, and folding pathways of multidomain proteins
著者 Itoh, Kazuhito

× Itoh, Kazuhito

WEKO 53827

Itoh, Kazuhito

Search repository
Sasai, Masaki

× Sasai, Masaki

WEKO 53828

Sasai, Masaki

Search repository
キーワード
主題Scheme Other
主題 energy landscape theory
キーワード
主題Scheme Other
主題 structure-based model
キーワード
主題Scheme Other
主題 circular permutation
抄録
内容記述 Multidomain proteins are ubiquitous in both prokaryotic and eukaryotic proteomes. Study on protein folding, however, has concentrated more on the isolated single domains of proteins, and there have been relatively few systematic studies on the effects of domain–domain interactions on folding. We here discuss this issue by examining human γD-crystallin, spore coat protein S, and a tandem array of the R16 and R17 domains of spectrin as example proteins by using a structure-based model of folding. The calculated results consistently explain the experimental data on folding pathways and effects of mutational perturbations, supporting the view that the connectivity of two domains and the distribution of domain–domain interactions in the native conformation are factors to determine kinetic and equilibrium properties of cooperative folding.
内容記述タイプ Abstract
出版者
出版者 National Academy of Sciences
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1091-6490
書誌情報 Proceedings of the National Academy of Sciences of the United States of America

巻 105, 号 37, p. 13865-13870, 発行日 2008-09
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1073/pnas.0804512105
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20615
識別子タイプ HDL
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