WEKO3
アイテム
{"_buckets": {"deposit": "6e212c43-e89c-4fc6-891c-091c94afbfa2"}, "_deposit": {"id": "18534", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18534"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00018534", "sets": ["322"]}, "author_link": ["53842", "53843"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "17", "bibliographicPageEnd": "7780", "bibliographicPageStart": "7775", "bibliographicVolumeNumber": "107", "bibliographic_titles": [{"bibliographic_title": "Proceedings of the National Academy of Sciences of the United States of America", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A statistical mechanical model of allosteric transitions in proteins is developed by extending the structure-based model of protein folding to cases of multiple native conformations. The partition function is calculated exactly within the model and the free-energy surface reflecting allostery is derived. This approach is applied to an example protein, the receiver domain of the bacterial enhancer-binding protein NtrC. The model predicts the large entropy associated with a combinatorial number of preexisting transition routes. This large entropy lowers the free-energy barrier of the allosteric transition, which explains the large structural fluctuation observed in the NMR data of NtrC. The global allosteric transformation of NtrC is explained by the shift of preexisting distribution of conformations upon phosphorylation, but the local structural adjustment around the phosphorylation site is explained by the complementary induced-fit mechanism. Structural disordering accompanied by fluctuating interactions specific to two allosteric conformations underlies a large number of routes of allosteric transition.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1073/pnas.0912978107"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/20620"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "National Academy of Sciences", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1073/pnas.0912978107", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1091-6490", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Itoh, Kazuhito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "53842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasai, Masaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "53843", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PNAS-2010-Itoh-7775-80.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "PNAS-2010-Itoh-7775-80.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/18534/files/PNAS-2010-Itoh-7775-80.pdf"}, "version_id": "f20b6991-d380-4030-8df0-1f65681c3d4c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "free-energy landscape", "subitem_subject_scheme": "Other"}, {"subitem_subject": "population shift", "subitem_subject_scheme": "Other"}, {"subitem_subject": "statistical mechanical model", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Entropic mechanism of large fluctuation in allosteric transition", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Entropic mechanism of large fluctuation in allosteric transition", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["322"], "permalink_uri": "http://hdl.handle.net/2237/20620", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-10-30"}, "publish_date": "2014-10-30", "publish_status": "0", "recid": "18534", "relation": {}, "relation_version_is_last": true, "title": ["Entropic mechanism of large fluctuation in allosteric transition"], "weko_shared_id": -1}
Entropic mechanism of large fluctuation in allosteric transition
http://hdl.handle.net/2237/20620
http://hdl.handle.net/2237/2062040ca87ed-9e47-487c-92cd-6072ab759ba4
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-10-30 | |||||
タイトル | ||||||
タイトル | Entropic mechanism of large fluctuation in allosteric transition | |||||
言語 | en | |||||
著者 |
Itoh, Kazuhito
× Itoh, Kazuhito× Sasai, Masaki |
|||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | free-energy landscape | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | population shift | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | statistical mechanical model | |||||
抄録 | ||||||
内容記述 | A statistical mechanical model of allosteric transitions in proteins is developed by extending the structure-based model of protein folding to cases of multiple native conformations. The partition function is calculated exactly within the model and the free-energy surface reflecting allostery is derived. This approach is applied to an example protein, the receiver domain of the bacterial enhancer-binding protein NtrC. The model predicts the large entropy associated with a combinatorial number of preexisting transition routes. This large entropy lowers the free-energy barrier of the allosteric transition, which explains the large structural fluctuation observed in the NMR data of NtrC. The global allosteric transformation of NtrC is explained by the shift of preexisting distribution of conformations upon phosphorylation, but the local structural adjustment around the phosphorylation site is explained by the complementary induced-fit mechanism. Structural disordering accompanied by fluctuating interactions specific to two allosteric conformations underlies a large number of routes of allosteric transition. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | National Academy of Sciences | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1073/pnas.0912978107 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1091-6490 | |||||
書誌情報 |
en : Proceedings of the National Academy of Sciences of the United States of America 巻 107, 号 17, p. 7775-7780, 発行日 2010-04 |
|||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1073/pnas.0912978107 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/20620 | |||||
識別子タイプ | HDL |