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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Entropic mechanism of large fluctuation in allosteric transition

http://hdl.handle.net/2237/20620
http://hdl.handle.net/2237/20620
40ca87ed-9e47-487c-92cd-6072ab759ba4
名前 / ファイル ライセンス アクション
PNAS-2010-Itoh-7775-80.pdf PNAS-2010-Itoh-7775-80.pdf (2.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-30
タイトル
タイトル Entropic mechanism of large fluctuation in allosteric transition
言語 en
著者 Itoh, Kazuhito

× Itoh, Kazuhito

WEKO 53842

en Itoh, Kazuhito

Search repository
Sasai, Masaki

× Sasai, Masaki

WEKO 53843

en Sasai, Masaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 free-energy landscape
キーワード
主題Scheme Other
主題 population shift
キーワード
主題Scheme Other
主題 statistical mechanical model
抄録
内容記述 A statistical mechanical model of allosteric transitions in proteins is developed by extending the structure-based model of protein folding to cases of multiple native conformations. The partition function is calculated exactly within the model and the free-energy surface reflecting allostery is derived. This approach is applied to an example protein, the receiver domain of the bacterial enhancer-binding protein NtrC. The model predicts the large entropy associated with a combinatorial number of preexisting transition routes. This large entropy lowers the free-energy barrier of the allosteric transition, which explains the large structural fluctuation observed in the NMR data of NtrC. The global allosteric transformation of NtrC is explained by the shift of preexisting distribution of conformations upon phosphorylation, but the local structural adjustment around the phosphorylation site is explained by the complementary induced-fit mechanism. Structural disordering accompanied by fluctuating interactions specific to two allosteric conformations underlies a large number of routes of allosteric transition.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 National Academy of Sciences
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.0912978107
ISSN
収録物識別子タイプ PISSN
収録物識別子 1091-6490
書誌情報 en : Proceedings of the National Academy of Sciences of the United States of America

巻 107, 号 17, p. 7775-7780, 発行日 2010-04
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1073/pnas.0912978107
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20620
識別子タイプ HDL
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