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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Dynamical Modeling of Three-Dimensional Genome Organization in Interphase Budding Yeast

http://hdl.handle.net/2237/20622
00060474-8a0f-4e39-877d-128510df705a
名前 / ファイル ライセンス アクション
TokudaTeradaSasaiBiophysJ2012.pdf TokudaTeradaSasaiBiophysJ2012.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-30
タイトル
タイトル Dynamical Modeling of Three-Dimensional Genome Organization in Interphase Budding Yeast
著者 Tokuda, Naoko

× Tokuda, Naoko

WEKO 53846

Tokuda, Naoko

Search repository
Terada, Tomoki P.

× Terada, Tomoki P.

WEKO 53847

Terada, Tomoki P.

Search repository
Sasai, Masaki

× Sasai, Masaki

WEKO 53848

Sasai, Masaki

Search repository
権利
権利情報 This is the author's version of a work that was accepted for publication in Biophysical Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biophysical Journal. v.102, n.2, 2012, p.296–304, DOI: 10.1016/j.bpj.2011.12.005
抄録
内容記述 Eukaryotic genome is organized in a set of chromosomes each of which consists of a chain of DNA and associated proteins. Processes involving DNA such as transcription, duplication, and repair, therefore, should be intrinsically related to the three-dimensional organization of the genome. In this article, we develop a computational model of the three-dimensional organization of the haploid genome of interphase budding yeast by regarding chromosomes as chains moving under the constraints of nuclear structure and chromatin-chromatin interactions. The simulated genome structure largely fluctuates with the diffusive movement of chromosomes. This fluctuation, however, is not completely random, as parts of chromosomes distribute in characteristic ways to form “territories” in the nucleus. By suitably taking account of constraints arising from the data of the chromosome-conformation-capture measurement, the model explains the observed fluorescence data of chromosome distributions and motions.
内容記述タイプ Abstract
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-3495
書誌情報 Biophysical Journal

巻 102, 号 2, p. 296-304, 発行日 2012-01
著者版フラグ
値 author
URI
識別子 http://dx.doi.org/10.1016/j.bpj.2011.12.005
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20622
識別子タイプ HDL
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