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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Non-Brownian dynamics and strategy of amoeboid cell locomotion

http://hdl.handle.net/2237/20623
http://hdl.handle.net/2237/20623
31e4f65d-15e6-41cc-b47b-ad5c589566e8
名前 / ファイル ライセンス アクション
PhysRevE_85_041909.pdf PhysRevE_85_041909.pdf (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-30
タイトル
タイトル Non-Brownian dynamics and strategy of amoeboid cell locomotion
言語 en
著者 Nishimura, Shin I.

× Nishimura, Shin I.

WEKO 53849

en Nishimura, Shin I.

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Ueda, Masahiro

× Ueda, Masahiro

WEKO 53850

en Ueda, Masahiro

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Sasai, Masaki

× Sasai, Masaki

WEKO 53851

en Sasai, Masaki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 ©2012 American Physical Society
抄録
内容記述タイプ Abstract
内容記述 Amoeboid cells such as Dictyostelium discoideum and Madin-Darby canine kidney cells show the non- Brownian dynamics of migration characterized by the superdiffusive increase of mean-squared displacement. In order to elucidate the physical mechanism of this non-Brownian dynamics, a computational model is developed which highlights a group of inhibitory molecules for actin polymerization. Based on this model, we propose a hypothesis that inhibitory molecules are sent backward in the moving cell to accumulate at the rear of cell. The accumulated inhibitory molecules at the rear further promote cell locomotion to form a slow positive feedback loop of the whole-cell scale. The persistent straightforward migration is stabilized with this feedback mechanism, but the fluctuation in the distribution of inhibitory molecules and the cell shape deformation concurrently interrupt the persistent motion to turn the cell into a new direction. A sequence of switching behaviors between persistent motions and random turns gives rise to the superdiffusive migration in the absence of the external guidance signal. In the complex environment with obstacles, this combined process of persistent motions and random turns drives the simulated amoebae to solve the maze problem in a highly efficient way, which suggests the biological advantage for cells to bear the non-Brownian dynamics.
言語 en
出版者
出版者 American Physical Society
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1103/PhysRevE.85.041909
ISSN
収録物識別子タイプ PISSN
収録物識別子 1539-3755
書誌情報 en : Physical Review E

巻 85, p. 041909-041909, 発行日 2012-04
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1103/PhysRevE.85.041909
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20623
識別子タイプ HDL
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