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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(1-2)

Minimal inflammogenicity of pristine single-wall carbon nanotubes

https://doi.org/10.18999/nagjms.77.1-2.195
https://doi.org/10.18999/nagjms.77.1-2.195
004e7cdc-8b84-4b63-b30c-e27060e0a741
名前 / ファイル ライセンス アクション
26_Toyokuni.pdf 26_Toyokuni.pdf (896.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-02-27
タイトル
タイトル Minimal inflammogenicity of pristine single-wall carbon nanotubes
著者 TOYOKUNI, SHINYA

× TOYOKUNI, SHINYA

WEKO 56059

TOYOKUNI, SHINYA

Search repository
LI, JIANG

× LI, JIANG

WEKO 56060

LI, JIANG

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KITAURA, RYO

× KITAURA, RYO

WEKO 56061

KITAURA, RYO

Search repository
SHINOHARA, HISANORI

× SHINOHARA, HISANORI

WEKO 56062

SHINOHARA, HISANORI

Search repository
キーワード
主題Scheme Other
主題 carbon nanotube
キーワード
主題Scheme Other
主題 inflammation
キーワード
主題Scheme Other
主題 mesothelioma
キーワード
主題Scheme Other
主題 human risk assessment
抄録
内容記述 Carbon nanotubes (CNTs) are a novel synthetic material comprising only carbon atoms. Based on its rigidity, its electrical and heat conductivity and its applicability to surface manufacturing, this material is expected to have numerous applications in industry. However, due to the material’s dimensional similarity to asbestos fibers, its carcinogenicity was hypothesized during the last decade, and indeed, we have shown that multi-wall CNTs (MWCNTs) of 50 nm in diameter are potently carcinogenic to mesothelial cells after intraperitoneal injection. Additionally, we suggested that inflammogenicity after intraperitoneal injection can predict mesothelial carcinogenesis. However, few data have been published on the intraperitoneal inflammogenicity of single-wall CNTs (SWCNTs). Here, we conducted a series of studies on SWCNTs using both intraperitoneal injection into rats and MeT5A mesothelial cells. Intraperitoneal injection of 10 mg SWCNTs caused no remarkable inflammation in the abdominal cavity, and the exposure of MeT5A cells to up to 25 μg/cm2 SWCNTs did not alter proliferation. MWCNTs of 50 nm in diameter were used as a positive control, and tangled MWCNTs of 15 nm in diameter were used as a negative control. The results suggest that SWCNTs are a low-risk material with respect to mesothelial carcinogenesis.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.1-2.195
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 1-2, p. 195-202, 発行日 2015-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/21272
識別子タイプ HDL
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