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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(1-2)

Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells

https://doi.org/10.18999/nagjms.77.1-2.253
https://doi.org/10.18999/nagjms.77.1-2.253
0d4cdb32-d87f-4188-bbe1-388ab7318cd0
名前 / ファイル ライセンス アクション
33_Kato.pdf 33_Kato.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-02-27
タイトル
タイトル Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells
著者 KATO, SHUICHI

× KATO, SHUICHI

WEKO 56098

KATO, SHUICHI

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KURIMOTO, SHIGERU

× KURIMOTO, SHIGERU

WEKO 56099

KURIMOTO, SHIGERU

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NAKANO, TOMONORI

× NAKANO, TOMONORI

WEKO 56100

NAKANO, TOMONORI

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YONEDA, HIDEMASA

× YONEDA, HIDEMASA

WEKO 56101

YONEDA, HIDEMASA

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ISHII, HISAO

× ISHII, HISAO

WEKO 56102

ISHII, HISAO

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MITA-SUGIURA, SATOKA

× MITA-SUGIURA, SATOKA

WEKO 56103

MITA-SUGIURA, SATOKA

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HIRATA, HITOSHI

× HIRATA, HITOSHI

WEKO 56104

HIRATA, HITOSHI

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キーワード
主題Scheme Other
主題 peripheral nerve
キーワード
主題Scheme Other
主題 motoneuron
キーワード
主題Scheme Other
主題 cell transplantation
キーワード
主題Scheme Other
主題 muscle reinnervation
キーワード
主題Scheme Other
主題 MISM
抄録
内容記述 Transplantation of motoneurons (MN) into the peripheral nerve to provide a source of neurons for muscle reinnervation, termed motoneuron integrated striated muscle (MISM), may provide the potential to restore functional muscle activity, when combined with computer-programmed functional electrical stimulation (FES). The number of MNs required to restore innervation to denervated muscles in adult Fischer 344 rats was investigated by comparing two groups, one transplanted with 2 × 105 cells (group A) and the other with 1 × 106 cells (group B). Twelve weeks after transplantation, electrophysiological analysis, muscle function analysis, and tissue analysis were performed. The mean motor nerve conduction velocity was faster (12.4 ± 1.0 m/s vs. 8.5 ± 0.7 m/s, P = 0.011) and the mean amplitude of compound muscle action potential was larger (1.6 ± 0.4 mV vs. 0.7 ± 0.2 mV, P = 0.034) in group B. The dorsiflexed ankle angle was larger in group B (27 ± 5° vs. 75 ± 8°, P = 0.02). The mean myelinated axon number in the peroneal nerve and the proportion of reinnervated motor end plates were also greater in group B (317 ± 33 vs. 104 ± 17, 87.5 ± 3.4% vs. 40.6 ± 7.7%; P < 0.01, respectively). When sufficient MNs are transplanted into the peripheral nerve, MISM forms functional motor units. MISM, in conjunction with FES, provides a new treatment strategy for paralyzed muscles.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.1-2.253
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 1-2, p. 253-263, 発行日 2015-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/21279
識別子タイプ HDL
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