{"_buckets": {"deposit": "8dd413ed-df92-4cac-9a14-98c11bfb5665"}, "_deposit": {"id": "19173", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19173"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00019173", "sets": ["1674"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "263", "bibliographicPageStart": "253", "bibliographicVolumeNumber": "77", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Transplantation of motoneurons (MN) into the peripheral nerve to provide a source of neurons for muscle reinnervation, termed motoneuron integrated striated muscle (MISM), may provide the potential to restore functional muscle activity, when combined with computer-programmed functional electrical stimulation (FES). The number of MNs required to restore innervation to denervated muscles in adult Fischer 344 rats was investigated by comparing two groups, one transplanted with 2 × 105 cells (group A) and the other with 1 × 106 cells (group B). Twelve weeks after transplantation, electrophysiological analysis, muscle function analysis, and tissue analysis were performed. The mean motor nerve conduction velocity was faster (12.4 ± 1.0 m/s vs. 8.5 ± 0.7 m/s, P = 0.011) and the mean amplitude of compound muscle action potential was larger (1.6 ± 0.4 mV vs. 0.7 ± 0.2 mV, P = 0.034) in group B. The dorsiflexed ankle angle was larger in group B (27 ± 5° vs. 75 ± 8°, P = 0.02). The mean myelinated axon number in the peroneal nerve and the proportion of reinnervated motor end plates were also greater in group B (317 ± 33 vs. 104 ± 17, 87.5 ± 3.4% vs. 40.6 ± 7.7%; P \u003c 0.01, respectively). When sufficient MNs are transplanted into the peripheral nerve, MISM forms functional motor units. MISM, in conjunction with FES, provides a new treatment strategy for paralyzed muscles.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/21279"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.77.1-2.253", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KATO, SHUICHI"}], "nameIdentifiers": [{"nameIdentifier": "56098", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KURIMOTO, SHIGERU"}], "nameIdentifiers": [{"nameIdentifier": "56099", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKANO, TOMONORI"}], "nameIdentifiers": [{"nameIdentifier": "56100", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YONEDA, HIDEMASA"}], "nameIdentifiers": [{"nameIdentifier": "56101", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ISHII, HISAO"}], "nameIdentifiers": [{"nameIdentifier": "56102", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MITA-SUGIURA, SATOKA"}], "nameIdentifiers": [{"nameIdentifier": "56103", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HIRATA, HITOSHI"}], "nameIdentifiers": [{"nameIdentifier": "56104", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "33_Kato.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "33_Kato.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/19173/files/33_Kato.pdf"}, "version_id": "bfdf5269-f751-42f2-a452-4072020b97a0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "peripheral nerve", "subitem_subject_scheme": "Other"}, {"subitem_subject": "motoneuron", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cell transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "muscle reinnervation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MISM", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells"}]}, "item_type_id": "9", "owner": "1", "path": ["1674"], "permalink_uri": "https://doi.org/10.18999/nagjms.77.1-2.253", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-02-27"}, "publish_date": "2015-02-27", "publish_status": "0", "recid": "19173", "relation": {}, "relation_version_is_last": true, "title": ["Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells"], "weko_shared_id": null}