{"created":"2021-03-01T06:26:38.561994+00:00","id":19173,"links":{},"metadata":{"_buckets":{"deposit":"8dd413ed-df92-4cac-9a14-98c11bfb5665"},"_deposit":{"created_by":17,"id":"19173","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"19173"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00019173","sets":["499:508:509:1674"]},"author_link":["56098","56099","56100","56101","56102","56103","56104"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"263","bibliographicPageStart":"253","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transplantation of motoneurons (MN) into the peripheral nerve to provide a source of neurons for muscle reinnervation, termed motoneuron integrated striated muscle (MISM), may provide the potential to restore functional muscle activity, when combined with computer-programmed functional electrical stimulation (FES). The number of MNs required to restore innervation to denervated muscles in adult Fischer 344 rats was investigated by comparing two groups, one transplanted with 2 × 105 cells (group A) and the other with 1 × 106 cells (group B). Twelve weeks after transplantation, electrophysiological analysis, muscle function analysis, and tissue analysis were performed. The mean motor nerve conduction velocity was faster (12.4 ± 1.0 m/s vs. 8.5 ± 0.7 m/s, P = 0.011) and the mean amplitude of compound muscle action potential was larger (1.6 ± 0.4 mV vs. 0.7 ± 0.2 mV, P = 0.034) in group B. The dorsiflexed ankle angle was larger in group B (27 ± 5° vs. 75 ± 8°, P = 0.02). The mean myelinated axon number in the peroneal nerve and the proportion of reinnervated motor end plates were also greater in group B (317 ± 33 vs. 104 ± 17, 87.5 ± 3.4% vs. 40.6 ± 7.7%; P < 0.01, respectively). When sufficient MNs are transplanted into the peripheral nerve, MISM forms functional motor units. MISM, in conjunction with FES, provides a new treatment strategy for paralyzed muscles.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/21279"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.77.1-2.253","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATO, SHUICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KURIMOTO, SHIGERU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKANO, TOMONORI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YONEDA, HIDEMASA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ISHII, HISAO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MITA-SUGIURA, SATOKA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRATA, HITOSHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"56104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-21"}],"displaytype":"detail","filename":"33_Kato.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"33_Kato.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/19173/files/33_Kato.pdf"},"version_id":"bfdf5269-f751-42f2-a452-4072020b97a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"peripheral nerve","subitem_subject_scheme":"Other"},{"subitem_subject":"motoneuron","subitem_subject_scheme":"Other"},{"subitem_subject":"cell transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle reinnervation","subitem_subject_scheme":"Other"},{"subitem_subject":"MISM","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1674"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-02-27"},"publish_date":"2015-02-27","publish_status":"0","recid":"19173","relation_version_is_last":true,"title":["Successful Transplantation of Motoneurons into the Peripheral Nerve Depends on the Number of Transplanted Cells"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:22:00.009791+00:00"}