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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(1-2)

Impact of the Intraoperative Use of Fibrinogen Concentrate for Hypofibrinogenemia during Thoracic Aortic Surgery

https://doi.org/10.18999/nagjms.77.1-2.265
https://doi.org/10.18999/nagjms.77.1-2.265
98bf246a-b37a-45e7-9405-61214bd76b1b
名前 / ファイル ライセンス アクション
34_Araki.pdf 34_Araki.pdf (197.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-02-27
タイトル
タイトル Impact of the Intraoperative Use of Fibrinogen Concentrate for Hypofibrinogenemia during Thoracic Aortic Surgery
著者 ARAKI, YOSHIMORI

× ARAKI, YOSHIMORI

WEKO 56105

ARAKI, YOSHIMORI

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USUI, AKIHIKO

× USUI, AKIHIKO

WEKO 56106

USUI, AKIHIKO

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OSHIMA, HIDEKI

× OSHIMA, HIDEKI

WEKO 56107

OSHIMA, HIDEKI

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ABE, TOMONOBU

× ABE, TOMONOBU

WEKO 56108

ABE, TOMONOBU

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FUJIMOTO, KAZURO

× FUJIMOTO, KAZURO

WEKO 56109

FUJIMOTO, KAZURO

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MUTSUGA, MASATO

× MUTSUGA, MASATO

WEKO 56110

MUTSUGA, MASATO

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TOKUDA, YOSHIYUKI

× TOKUDA, YOSHIYUKI

WEKO 56111

TOKUDA, YOSHIYUKI

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TERAZAWA, SACHIE

× TERAZAWA, SACHIE

WEKO 56112

TERAZAWA, SACHIE

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YAGAMI, KEI

× YAGAMI, KEI

WEKO 56113

YAGAMI, KEI

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ITO, HIDEKI

× ITO, HIDEKI

WEKO 56114

ITO, HIDEKI

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キーワード
主題Scheme Other
主題 fibrinogen concentrate
キーワード
主題Scheme Other
主題 coagulopathy
キーワード
主題Scheme Other
主題 thoracic aortic surgery
抄録
内容記述 Thoracic aortic surgery often causes massive bleeding due to coagulopathy. Hypofibrinogenemia is one of the major causative factors, but the utility of the intraoperative administration of fibrinogen concentrate has not yet been proven. The aim of this study was to estimate incidence of hypofibrinogenemia and to evaluate efficacy of using fibrinogen concentrate intraoperatively. The perioperative serum fibrinogen levels (SFL) had routinely been measured in consecutive 216 thoracic aortic surgeries performed from 2010 to 2012. Fibrinogen concentrate was principally used for hypofibrinogenemia (< 150 mg/dl of SFL) at cardiopulmonary bypass (CPB) termination. The patients who received fibrinogen concentrate (FIB group) were compared with the patients who did not received (non Fib group). There were 147 patients (68%) in FIB group at a dose of 5.5±3.5 g. The SFL were dramatically decreased with values of 164±71 mg/dl at CPB termination, compared to the preoperative SFL of 352±131 mg/dl. In the FIB group, the intraoperative and postoperative SFLs were 139±53 and 262±75 (mg/dl), respectively. Thus the SFL was recovered quickly by the administration. 110 cases (51%) showed hypofibrinogenemia at the termination of CPB. The predictors of hypofibrinogenemia were preoperative SFL < 250 mg/dl, emergency surgery and thracoabdominal aortic surgery. Hypofibrinogenemia frequently was observed at the termination of CPB during thoracic aortic surgery. Administering intraoperative fibrinogen concentrate appears to be a useful option to treat coagulopathy.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.1-2.265
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 1-2, p. 265-273, 発行日 2015-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/21280
識別子タイプ HDL
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