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Roles of Oxidative Stress and the Mineralocorticoid Receptor in Cardiac Pathology in a Rat Model of Metabolic Syndrome
https://doi.org/10.18999/nagjms.77.1-2.275
https://doi.org/10.18999/nagjms.77.1-2.275642eafb2-adde-456f-b432-f46411a55eec
名前 / ファイル | ライセンス | アクション |
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35_Takahashi.pdf (913.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-02-27 | |||||
タイトル | ||||||
タイトル | Roles of Oxidative Stress and the Mineralocorticoid Receptor in Cardiac Pathology in a Rat Model of Metabolic Syndrome | |||||
言語 | en | |||||
著者 |
TAKAHASHI, KEIJI
× TAKAHASHI, KEIJI× MURASE, TAMAYO× TAKATSU, MIWA× MATSUURA, NATSUMI× NAGASAWA, KAI× HATTORI, TAKUYA× WATANABE, SHOGO× MUROHARA, TOYOAKI× NAGATA, KOHZO |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metabolic syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardiac remodeling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxidative stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mineralocorticoid receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | renin-angiotensin-aldosterone system | |||||
抄録 | ||||||
内容記述 | Oxidative stress and the mineralocorticoid receptor (MR) are implicated in the pathogenesis of saltinduced left ventricular (LV) diastolic dysfunction associated with metabolic syndrome (MetS). We recently characterized DahlS.Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of MetS. We investigated the pathophysiological roles of increased oxidative stress and MR activation in cardiac injury with this model. DS/obese rats were treated with the antioxidant tempol (1 mmol/L in drinking water) or the selective MR antagonist eplerenone (15 mg/kg per day, per os) for 5 weeks beginning at 10 weeks of age. The increased systolic blood pressure and LV hypertrophy that develop in untreated DS/obese rats were substantially ameliorated by eplerenone but not by tempol. Eplerenone also attenuated LV fibrosis and diastolic dysfunction more effectively than did tempol in DS/obese rats, whereas cardiac oxidative stress and inflammation were reduced similarly by both drugs. Both the ratio of plasma aldosterone concentration to plasma renin activity and cardiac expression of the MR and serum/glucocorticoid–regulated kinase 1 genes were decreased to a greater extent by eplerenone than by tempol. Our results indicate that both increased oxidative stress and MR activation in the heart may contribute to the development of LV remodeling and diastolic dysfunction in DS/obese rats. The superior cardioprotective action of eplerenone is likely attributable to its greater antihypertensive effect, which is likely related to its greater inhibition of aldosterone-MR activity in the cardiovascular system. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.77.1-2.275 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 77, 号 1-2, p. 275-289, 発行日 2015-02 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/21281 | |||||
識別子タイプ | HDL |