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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(1-2)

Roles of Oxidative Stress and the Mineralocorticoid Receptor in Cardiac Pathology in a Rat Model of Metabolic Syndrome

https://doi.org/10.18999/nagjms.77.1-2.275
https://doi.org/10.18999/nagjms.77.1-2.275
642eafb2-adde-456f-b432-f46411a55eec
名前 / ファイル ライセンス アクション
35_Takahashi.pdf 35_Takahashi.pdf (913.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-02-27
タイトル
タイトル Roles of Oxidative Stress and the Mineralocorticoid Receptor in Cardiac Pathology in a Rat Model of Metabolic Syndrome
著者 TAKAHASHI, KEIJI

× TAKAHASHI, KEIJI

WEKO 56115

TAKAHASHI, KEIJI

Search repository
MURASE, TAMAYO

× MURASE, TAMAYO

WEKO 56116

MURASE, TAMAYO

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TAKATSU, MIWA

× TAKATSU, MIWA

WEKO 56117

TAKATSU, MIWA

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MATSUURA, NATSUMI

× MATSUURA, NATSUMI

WEKO 56118

MATSUURA, NATSUMI

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NAGASAWA, KAI

× NAGASAWA, KAI

WEKO 56119

NAGASAWA, KAI

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HATTORI, TAKUYA

× HATTORI, TAKUYA

WEKO 56120

HATTORI, TAKUYA

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WATANABE, SHOGO

× WATANABE, SHOGO

WEKO 56121

WATANABE, SHOGO

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MUROHARA, TOYOAKI

× MUROHARA, TOYOAKI

WEKO 56122

MUROHARA, TOYOAKI

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NAGATA, KOHZO

× NAGATA, KOHZO

WEKO 56123

NAGATA, KOHZO

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キーワード
主題Scheme Other
主題 metabolic syndrome
キーワード
主題Scheme Other
主題 cardiac remodeling
キーワード
主題Scheme Other
主題 oxidative stress
キーワード
主題Scheme Other
主題 mineralocorticoid receptor
キーワード
主題Scheme Other
主題 renin-angiotensin-aldosterone system
抄録
内容記述 Oxidative stress and the mineralocorticoid receptor (MR) are implicated in the pathogenesis of saltinduced left ventricular (LV) diastolic dysfunction associated with metabolic syndrome (MetS). We recently characterized DahlS.Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of MetS. We investigated the pathophysiological roles of increased oxidative stress and MR activation in cardiac injury with this model. DS/obese rats were treated with the antioxidant tempol (1 mmol/L in drinking water) or the selective MR antagonist eplerenone (15 mg/kg per day, per os) for 5 weeks beginning at 10 weeks of age. The increased systolic blood pressure and LV hypertrophy that develop in untreated DS/obese rats were substantially ameliorated by eplerenone but not by tempol. Eplerenone also attenuated LV fibrosis and diastolic dysfunction more effectively than did tempol in DS/obese rats, whereas cardiac oxidative stress and inflammation were reduced similarly by both drugs. Both the ratio of plasma aldosterone concentration to plasma renin activity and cardiac expression of the MR and serum/glucocorticoid–regulated kinase 1 genes were decreased to a greater extent by eplerenone than by tempol. Our results indicate that both increased oxidative stress and MR activation in the heart may contribute to the development of LV remodeling and diastolic dysfunction in DS/obese rats. The superior cardioprotective action of eplerenone is likely attributable to its greater antihypertensive effect, which is likely related to its greater inhibition of aldosterone-MR activity in the cardiovascular system.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.1-2.275
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 1-2, p. 275-289, 発行日 2015-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/21281
識別子タイプ HDL
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