@article{oai:nagoya.repo.nii.ac.jp:02000213,
 author = {Tanaka, Satoshi and Ando, Kei and Kobayashi, Kazuyoshi and Nakashima, Hiroaki and Seki, Taisuke and Ishizuka, Shinya and Machino, Masaaki and Morozumi, Masayoshi and Kanbara, Shunsuke and Ito, Sadayuki and Kanemura, Tokumi and Ishiguro, Naoki and Hasegawa, Yukiharu and Imagama, Shiro},
 issue = {1},
 journal = {Nagoya Journal of Medical Science},
 month = {Feb},
 note = {Japan’s aging society is facing an increase in the prevalence of frailty and locomotive syndrome (LS) among older adults. To evaluate the association of these age-related declines on health-related quality of life (QOL) in Japan, we investigated this relationship among Japanese middle-aged and older adults who underwent general checkups and examined whether LS or frailty has a stronger association with the Japanese version of EuroQol’s five-level EQ-5D (EQ-5D-5L) index. Participants were 231 middle-aged and older Japanese adults receiving routine health checkups. The study utilized the 25-item Geriatric Locomotive Function Scale, the Japanese version of the Cardiovascular Health Study, and the Japanese version of the EQ-5D-5L. Univariate and multivariate analyses were performed to examine how frailty and LS are related to the EQ-5D-5L index. Patients with both frailty (p = 0.003) and LS (p < 0.001) had a significantly lower EQ-5D-5L index. After adjusting for age, gender, and body mass index, LS was significantly associated with a decrease in the EQ-5D-5L index (p < 0.001), whereas frailty had no significant association with the EQ-5D-5L index (p = 0.052). Further analysis showed no significant decrease in the EQ-5D-5L index among those with frailty but no LS, and a significant decrease among those with frailty and LS. The results suggest that frailty and LS are associated with a decrease in the EQ-5D-5L index, but LS has a more pronounced effect. In evaluating frailty’s effects on health-related QOL, we determined the importance of separately assessing frailty both with and without LS, even within the same frailty group.},
 pages = {159--167},
 title = {The dual presence of frailty and locomotive syndrome is associated with a greater decrease in the EQ-5D-5L index},
 volume = {83},
 year = {2021}
}