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Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging
http://hdl.handle.net/2237/0002001413
http://hdl.handle.net/2237/0002001413e12579c2-bf9e-4ed9-8df5-78e7a173bd5f
名前 / ファイル | ライセンス | アクション |
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konishi.pdf (977 KB)
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Item type | itemtype_ver1(1) | |||||||||
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公開日 | 2021-09-09 | |||||||||
タイトル | ||||||||||
タイトル | Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging | |||||||||
言語 | en | |||||||||
著者 |
Konishi, Hiroyuki
× Konishi, Hiroyuki
× Kiyama, Hiroshi
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Aging | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | DAP12 | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Development | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Homeostasis | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | Microglia | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | TREM2 | |||||||||
内容記述 | ||||||||||
内容記述 | Triggering receptor expressed on myeloid cells 2 (TREM2) forms a receptor complex with DNAX-activating protein of 12 kDa (DAP12) on the microglial plasma membrane. A wide variety of protein and non-protein ligands, including lipids and DNA, can bind to TREM2, inducing the activation of microglia via DAP12. Both Trem2 and Dap12 have been identified as causative genes for Nasu-Hakola disease, which causes presenile dementia in association with bone cysts. Furthermore, TREM2/DAP12 signaling represents an essential inducer of the activated microglial phenotype in neuronal diseases, including Alzheimer's disease. Therefore, most previous studies examining TREM2/DAP12 have focused on their roles in microglia under pathological conditions. However, a growing body of evidence has demonstrated the involvement of TREM2/DAP12 signaling in the regulation of physiological functions in microglia. Accordingly, by examining the importance of TREM2/DAP12 in the regulation of microglial activity during development, homeostasis, and aging in the brain, this review elucidates the roles played by this complex in the healthy brain. | |||||||||
言語 | en | |||||||||
内容記述タイプ | Abstract | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Elsevier | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
資源タイプ | ||||||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||||||
タイプ | journal article | |||||||||
出版タイプ | ||||||||||
出版タイプ | AM | |||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
関連情報 | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1016/j.neuint.2020.104878 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 01970186 | |||||||||
書誌情報 |
en : Neurochemistry International 巻 141, p. 104878, 発行日 2020-12 |
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ファイル公開日 | ||||||||||
日付 | 2021-12-01 | |||||||||
日付タイプ | Available |