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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging

http://hdl.handle.net/2237/0002001413
http://hdl.handle.net/2237/0002001413
e12579c2-bf9e-4ed9-8df5-78e7a173bd5f
名前 / ファイル ライセンス アクション
konishi.pdf konishi.pdf (977 KB)
Item type itemtype_ver1(1)
公開日 2021-09-09
タイトル
タイトル Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging
言語 en
著者 Konishi, Hiroyuki

× Konishi, Hiroyuki

en Konishi, Hiroyuki

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Kiyama, Hiroshi

× Kiyama, Hiroshi

en Kiyama, Hiroshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Aging
キーワード
主題Scheme Other
主題 DAP12
キーワード
主題Scheme Other
主題 Development
キーワード
主題Scheme Other
主題 Homeostasis
キーワード
主題Scheme Other
主題 Microglia
キーワード
主題Scheme Other
主題 TREM2
内容記述
内容記述 Triggering receptor expressed on myeloid cells 2 (TREM2) forms a receptor complex with DNAX-activating protein of 12 kDa (DAP12) on the microglial plasma membrane. A wide variety of protein and non-protein ligands, including lipids and DNA, can bind to TREM2, inducing the activation of microglia via DAP12. Both Trem2 and Dap12 have been identified as causative genes for Nasu-Hakola disease, which causes presenile dementia in association with bone cysts. Furthermore, TREM2/DAP12 signaling represents an essential inducer of the activated microglial phenotype in neuronal diseases, including Alzheimer's disease. Therefore, most previous studies examining TREM2/DAP12 have focused on their roles in microglia under pathological conditions. However, a growing body of evidence has demonstrated the involvement of TREM2/DAP12 signaling in the regulation of physiological functions in microglia. Accordingly, by examining the importance of TREM2/DAP12 in the regulation of microglial activity during development, homeostasis, and aging in the brain, this review elucidates the roles played by this complex in the healthy brain.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.neuint.2020.104878
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 01970186
書誌情報 en : Neurochemistry International

巻 141, p. 104878, 発行日 2020-12
ファイル公開日
日付 2021-12-01
日付タイプ Available
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