{"created":"2021-09-13T01:05:21.040117+00:00","id":2001431,"links":{},"metadata":{"_buckets":{"deposit":"87b22abe-c2b0-491b-a430-a6cd3d13bd91"},"_deposit":{"created_by":17,"id":"2001431","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2001431"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02001431","sets":["320:321:322"]},"author_link":[],"control_number":"2001431","item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1629683748249":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-01","subitem_date_issued_type":"Available"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"752","bibliographicPageStart":"743","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"Annals of Hematology","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"To overcome the delayed or failed engraftment after unrelated cord blood transplantation (CBT), we conducted a multicenter phase II study of intrabone single-unit CBT without antithymocyte globulin (ATG) for adult patients with hematological malignancies (UMIN-CTR, UMIN000020997). Sixty-four patients received an intrabone injection of unwashed (n = 61) or washed (n = 3) cord blood after local anesthesia. All injection-related adverse events were mild and resolved spontaneously. Sixty-two patients were evaluable for the efficacy of intrabone CBT of serological HLA-A, -B, and -DR ≥ 4/6 matched cord blood with a median number of 2.57 × 10^7/kg cryopreserved total nucleated cells. The probability of survival with neutrophil engraftment on day 28 was 77.4% (95% confidence interval, 67.0–85.8%), which exceeded the threshold value. The cumulative incidences of neutrophils ≥ 0.5 × 10^9/L on day 60 was 80.6% (68.2–88.6%), with a median time to recovery of 21 days after transplantation. The cumulative incidences of platelets ≥ 20 × 10^9/L and platelets ≥ 50 × 10^9/L on day 100 were 75.8% (62.6–84.9%) and 72.6% (59.4–82.1%), respectively, with median time to platelets ≥ 20 × 10^9/L and platelets ≥ 50 × 10^9/L of 38 and 45 days after transplantation, respectively. The cumulative incidences of grade II–IV and III–IV acute graft-versus-host disease were 29.0% and 6.5%, respectively. All responded to steroid therapy, and secondary treatments were not required. The present study suggests the efficacy of intrabone single-unit CBT without ATG in terms of early engraftment and controllable acute graft-versus-host disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00277-020-04365-z","subitem_relation_type_select":"DOI"}}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0939-5555","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishida, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawa, Masashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Masuda, Shinichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shibasaki, Yasuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Goto, Tatsunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukuhara, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujii, Nobuharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ikegame, Kazuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugita, Junichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ikeda, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuwatsuka, Yachiyo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Ritsuro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Najima, Yuho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Doki, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kato, Tomonori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inagaki, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Utsu, Yoshikazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aotsuka, Nobuyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Masuko, Masayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Terakura, Seitaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Onishi, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maeda, Yoshinobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okada, Masaya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Teshima, Takanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murata, Makoto","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-01"}],"displaytype":"detail","filename":"Ann_Hematol_2021.pdf","filesize":[{"value":"351 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2001431/files/Ann_Hematol_2021.pdf"},"version_id":"880589dc-d2ad-4b38-86c0-4bf93e53135a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cord blood transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"intrabone, engraftment","subitem_subject_scheme":"Other"},{"subitem_subject":"graft-versus-host disease","subitem_subject_scheme":"Other"},{"subitem_subject":"antithymocyte globulin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["322"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-13"},"publish_date":"2021-09-13","publish_status":"0","recid":"2001431","relation_version_is_last":true,"title":["A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-01-16T05:02:14.995001+00:00"}