{"created":"2021-12-03T01:40:40.658758+00:00","id":2001651,"links":{},"metadata":{"_buckets":{"deposit":"8611da20-18e5-4a29-8d45-74978b4f6f6c"},"_deposit":{"created_by":17,"id":"2001651","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2001651"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02001651","sets":["499:508:509:1638493189962"]},"author_link":[],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1615768833594":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"16H05413","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05413/"},"subitem_award_titles":[{"subitem_award_title":"HF10ウイルスの抗腫瘍効果における新たな免疫因子の役割","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"16K15611","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15611/"},"subitem_award_titles":[{"subitem_award_title":"革新的な腫瘍抗原ウイルスとTCR遺伝子改変T細胞の併用療法の開発","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"696","bibliographicPageStart":"683","bibliographicVolumeNumber":"83","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Canerpaturev (C-REV) is a highly attenuated, replication-competent, mutant strain of oncolytic herpes simplex virus type 1 that may be an effective new cancer treatment option. S-1, an oral formulation containing the 5-fluorouracil (5-FU) prodrug tegafur and the two enzyme modulators gimeracil and oteracil, is used as a key chemotherapeutic agent for metastatic recurrent breast cancer. Although the antitumor effects of oncolytic viruses combined with 5-FU in vivo have been reported, the detailed mechanisms are unknown. Here, we investigated the antitumor mechanism of the combination of C-REV and S-1 in triple-negative breast cancer (TNBC) in the context of tumor immunity. The combined effect of C-REV and S-1 was evaluated in a bilateral tumor model of murine TNBC 4T1 in vivo. S-1 enhanced the TNBC growth inhibitory effects of C-REV, and decreased the number of tumor-infiltrating, myeloid-derived suppressor cells (MDSCs), which suppress both innate and adaptive immune responses. Moreover, C-REV alone and in combination with S-1 significantly increased the number of CD8+ T cells in the tumor and the production of interferon γ (IFNγ) from these cells. Our findings indicate that C-REV suppresses TNBC tumor growth by inducing the expansion of effector CD8+ T cell subsets in tumors in which S-1 can inhibit MDSC function. Our study suggests that MDSCs may be an important cellular target for breast cancer treatment. The combination of C-REV and S-1 is a new approach that might be directly translated into future clinical trials against TNBC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.83.4.683","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/834.html","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyajima, Noriyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ragab Eissa, Ibrahim","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Abdelmoneim, Mohamed","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Naoe, Yoshinori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ichinose, Toru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumura, Shigeru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Bustos-Villalobos, Itzel","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mukoyama, Nobuaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Morimoto, Daishi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shibata, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takeuchi, Dai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsunoda, Nobuyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kikumori, Toyone","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Maki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kodera, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kasuya, Hideki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-03"}],"displaytype":"detail","filename":"04_Miyajima.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2001651/files/04_Miyajima.pdf"},"version_id":"627ae227-7fd0-4d2f-ab93-6edeac5f1d9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oncolytic virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"canerpaturev","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"myeloid-derived suppressor cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["1638493189962"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-03"},"publish_date":"2021-12-03","publish_status":"0","recid":"2001651","relation_version_is_last":true,"title":["S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T01:56:08.527386+00:00"}