@article{oai:nagoya.repo.nii.ac.jp:02001897,
 author = {Kurauchi, Tatsuhiro and Matsui, Kotaro and Shimasaki, Takafumi and Ohtsuka, Hokuto and Tsubouchi, Satoshi and Ihara, Kunio and Tani, Motohiro and Aiba, Hirofumi},
 issue = {12},
 journal = {FEMS Microbiology Letters},
 month = {Jun},
 note = {Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2^+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2^+ gene.},
 title = {Identification of sur2 mutation affecting the lifespan of fission yeast},
 volume = {368},
 year = {2021}
}