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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks

http://hdl.handle.net/2237/0002002059
http://hdl.handle.net/2237/0002002059
88fa3230-71f4-45b5-911b-2545e2c0a9af
名前 / ファイル ライセンス アクション
manuscript-0728.pdf manuscript-0728.pdf (2.2 MB)
Item type itemtype_ver1(1)
公開日 2022-02-09
タイトル
タイトル Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks
言語 en
著者 Liao, Jingzhu

× Liao, Jingzhu

en Liao, Jingzhu

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Dong, Geyao

× Dong, Geyao

en Dong, Geyao

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Wulaer, Bolati

× Wulaer, Bolati

en Wulaer, Bolati

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Sawahata, Masahito

× Sawahata, Masahito

en Sawahata, Masahito

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Mizoguchi, Hiroyuki

× Mizoguchi, Hiroyuki

en Mizoguchi, Hiroyuki

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Mori, Daisuke

× Mori, Daisuke

en Mori, Daisuke

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Ozaki, Norio

× Ozaki, Norio

en Ozaki, Norio

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Nabeshima, Toshitaka

× Nabeshima, Toshitaka

en Nabeshima, Toshitaka

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Nagai, Taku

× Nagai, Taku

en Nagai, Taku

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Yamada, Kiyofumi

× Yamada, Kiyofumi

en Yamada, Kiyofumi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述 The Reelin gene (RELN) encodes a large extracellular protein, which has multiple roles in brain development and adult brain function. It activates a series of neuronal signal transduction pathways in the adult brain that function in synaptic plasticity, dendritic morphology, and cognitive function. To further investigate the roles of Reln in brain function, we generated a mouse line using the C57BL/6 J strain with the specific Reln deletion identified from a Japanese patient with schizophrenia (Reln-del mice). These mice exhibited abnormal sociality, but the pathophysiological significance of the Reln deletion for higher brain functions, such as learning and behavioral flexibility remains unclear. In this study, cognitive function in Reln-del mice was assessed using touchscreen-based visual discrimination (VD) and reversal learning (RL) tasks. Reln-del mice showed normal learning in the simple VD task, but the learning was delayed in the complex VD task as compared to their wild-type (WT) littermates. In the RL task, sessions were divided into early perseverative phase (sessions with <50% correct) and later learning phase (sessions with ≥50% correct). Reln-del mice showed normal perseveration but impaired relearning ability in both simple RL and complex RL task as compared to WT mice. These results suggest that Reln-del mice have impaired learning ability, but the behavioral flexibility is unaffected. Overall, the observed behavioral abnormalities in Reln-del mice suggest that this mouse model is a useful preclinical tool for investigating the neurobiological mechanism underlying cognitive impairments in schizophrenia and a therapeutic strategy.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bbr.2021.113569
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0166-4328
書誌情報 en : Behavioural Brain Research

巻 416, p. 113569, 発行日 2022-01-07
ファイル公開日
日付 2023-01-07
日付タイプ Available
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