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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study

http://hdl.handle.net/2237/0002002063
http://hdl.handle.net/2237/0002002063
3d5f7337-9b9d-427a-a52d-79b21a135608
名前 / ファイル ライセンス アクション
HDP_and_VBM.pdf HDP_and_VBM.pdf (417 KB)
Item type itemtype_ver1(1)
公開日 2022-02-09
タイトル
タイトル Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study
言語 en
著者 Ushida, Takafumi

× Ushida, Takafumi

en Ushida, Takafumi

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Kidokoro, Hiroyuki

× Kidokoro, Hiroyuki

en Kidokoro, Hiroyuki

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Nakamura, Noriyuki

× Nakamura, Noriyuki

en Nakamura, Noriyuki

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Katsuki, Satoru

× Katsuki, Satoru

en Katsuki, Satoru

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Imai, Kenji

× Imai, Kenji

en Imai, Kenji

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Nakano-Kobayashi, Tomoko

× Nakano-Kobayashi, Tomoko

en Nakano-Kobayashi, Tomoko

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Moriyama, Yoshinori

× Moriyama, Yoshinori

en Moriyama, Yoshinori

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Sato, Yoshiaki

× Sato, Yoshiaki

en Sato, Yoshiaki

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Hayakawa, Masahiro

× Hayakawa, Masahiro

en Hayakawa, Masahiro

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Natsume, Jun

× Natsume, Jun

en Natsume, Jun

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Kajiyama, Hiroaki

× Kajiyama, Hiroaki

en Kajiyama, Hiroaki

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Kotani, Tomomi

× Kotani, Tomomi

en Kotani, Tomomi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述 Objectives: Infants born to mothers with hypertensive disorders of pregnancy (HDP) reportedly have negative behavioral and neurodevelopmental outcomes. However, the effects of maternal HDP on infant brain growth have not been fully evaluated. We aimed to evaluate brain volumes and brain injury in preterm infants born to mothers with HDP using magnetic resonance (MR) imaging at term-equivalent age. Study design: In this cohort study, MR imaging was performed for 94 preterm infants born before 34 weeks of gestation at Nagoya University Hospital between 2010 and 2018. Twenty infants were born to mothers with HDP and 74 to mothers without HDP. Main outcome measures: Total brain volumes and regional volumetric alterations were assessed by voxel-based morphometry, and brain injury was evaluated using the Kidokoro global brain abnormality score. Developmental quotient was assessed at a corrected age of 1.5 years in 59 infants (HDP, n = 11; non-HDP, n = 48). Results: No significant differences were observed in the gray and white matter volumes of the two groups (HDP: 175 ± 24 mL, 137 ± 13 mL, respectively; non-HDP: 172 ± 24 mL, 142 ± 13 mL, respectively). Additionally, no regional volumetric alterations were observed between the two groups after covariate adjustment (gestational age and infant sex). The total Kidokoro score and developmental quotient were similar in both groups. Conclusions: No significant differences in the global and regional brain volumes were observed. Further research is needed to confirm our findings at different time points of MR imaging and in different populations.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.preghy.2021.06.003
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 2210-7789
書誌情報 en : Pregnancy Hypertension

巻 25, p. 143-149, 発行日 2021-08
ファイル公開日
日付 2022-08-01
日付タイプ Available
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