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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy Trial

http://hdl.handle.net/2237/0002002069
394d1a9a-5ffb-4117-b997-af892220d797
名前 / ファイル ライセンス アクション
Main_manuscript_document_LCI.pdf Main_manuscript_document_LCI.pdf (711 KB)
 Download is available from 2022/7/31.
Item type itemtype_ver1(1)
公開日 2022-02-10
タイトル
タイトル Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy Trial
言語 en
著者 Hasegawa, Issei

× Hasegawa, Issei

en Hasegawa, Issei

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Yamamura, Takeshi

× Yamamura, Takeshi

en Yamamura, Takeshi

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Suzuki, Hiroto

× Suzuki, Hiroto

en Suzuki, Hiroto

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Maeda, Keiko

× Maeda, Keiko

en Maeda, Keiko

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Sawada, Tsunaki

× Sawada, Tsunaki

en Sawada, Tsunaki

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Mizutani, Yasuyuki

× Mizutani, Yasuyuki

en Mizutani, Yasuyuki

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Ishikawa, Eri

× Ishikawa, Eri

en Ishikawa, Eri

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Ishikawa, Takuya

× Ishikawa, Takuya

en Ishikawa, Takuya

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Kakushima, Naomi

× Kakushima, Naomi

en Kakushima, Naomi

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Furukawa, Kazuhiro

× Furukawa, Kazuhiro

en Furukawa, Kazuhiro

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Ohno, Eizaburo

× Ohno, Eizaburo

en Ohno, Eizaburo

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Kawashima, Hiroki

× Kawashima, Hiroki

en Kawashima, Hiroki

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Nakamura, Masanao

× Nakamura, Masanao

en Nakamura, Masanao

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Fujishiro, Mitsuhiro

× Fujishiro, Mitsuhiro

en Fujishiro, Mitsuhiro

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アクセス権
アクセス権 embargoed access
アクセス権URI http://purl.org/coar/access_right/c_f1cf
権利
言語 en
権利情報 © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述 Background and aims: A higher adenoma detection rate (ADR) has been shown to be related to a lower incidence and mortality of colorectal cancer. We analyzed the efficacy of linked color imaging (LCI) by assessing the detection, miss, and visibility of various featured adenomas as compared with white light imaging (WLI). Methods: This was a prospective, randomized, tandem trial. The participants were randomly assigned to 2 groups: first observation by LCI, then second observation by WLI (LCI group); or both observations by WLI (WLI group). Suspected neoplastic lesions were resected after magnifying image-enhanced endoscopy. The primary outcome was to compare the ADR during the first observation. Secondary outcomes included evaluation of adenoma miss rate (AMR) and visibility score. Results: A total of 780 patients were randomized, 700 of whom were included in the final analysis. The ADR was 69.6% and 63.2% in the LCI and WLI groups, respectively, with no significant difference. However, LCI improved the average ADR in low-detectors compared with high-detectors (76.0% vs 55.1%; P < .001). Total AMR was 20.6% in the LCI group, which was significantly lower than that in the WLI group (31.1%) (P < .001). AMR in the LCI group was significantly lower, especially for diminutive adenomas (23.4% vs 35.1%; P < .001) and nonpolypoid lesions (25.6% vs 37.9%; P < .001) compared with the WLI group. Conclusion: Although both methods provided a similar ADR, LCI had a lower AMR than WLI. LCI could benefit endoscopists with lower ADR, an observation that warrants additional study. (UMIN Clinical Trials Registry, Number: UMIN000026359).
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.cgh.2021.04.004
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1542-3565
書誌情報 en : Clinical Gastroenterology and Hepatology

巻 19, 号 8, p. 1708-1716.e4, 発行日 2021-08
ファイル公開日
日付 2022-08-01
日付タイプ Available
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