@article{oai:nagoya.repo.nii.ac.jp:02002069,
 author = {Hasegawa, Issei and Yamamura, Takeshi and Suzuki, Hiroto and Maeda, Keiko and Sawada, Tsunaki and Mizutani, Yasuyuki and Ishikawa, Eri and Ishikawa, Takuya and Kakushima, Naomi and Furukawa, Kazuhiro and Ohno, Eizaburo and Kawashima, Hiroki and Nakamura, Masanao and Fujishiro, Mitsuhiro},
 issue = {8},
 journal = {Clinical Gastroenterology and Hepatology},
 month = {Aug},
 note = {Background and aims: A higher adenoma detection rate (ADR) has been shown to be related to a lower incidence and mortality of colorectal cancer. We analyzed the efficacy of linked color imaging (LCI) by assessing the detection, miss, and visibility of various featured adenomas as compared with white light imaging (WLI). Methods: This was a prospective, randomized, tandem trial. The participants were randomly assigned to 2 groups: first observation by LCI, then second observation by WLI (LCI group); or both observations by WLI (WLI group). Suspected neoplastic lesions were resected after magnifying image-enhanced endoscopy. The primary outcome was to compare the ADR during the first observation. Secondary outcomes included evaluation of adenoma miss rate (AMR) and visibility score. Results: A total of 780 patients were randomized, 700 of whom were included in the final analysis. The ADR was 69.6% and 63.2% in the LCI and WLI groups, respectively, with no significant difference. However, LCI improved the average ADR in low-detectors compared with high-detectors (76.0% vs 55.1%; P < .001). Total AMR was 20.6% in the LCI group, which was significantly lower than that in the WLI group (31.1%) (P < .001). AMR in the LCI group was significantly lower, especially for diminutive adenomas (23.4% vs 35.1%; P < .001) and nonpolypoid lesions (25.6% vs 37.9%; P < .001) compared with the WLI group. Conclusion: Although both methods provided a similar ADR, LCI had a lower AMR than WLI. LCI could benefit endoscopists with lower ADR, an observation that warrants additional study. (UMIN Clinical Trials Registry, Number: UMIN000026359).},
 pages = {1708--1716.e4},
 title = {Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy Trial},
 volume = {19},
 year = {2021}
}