{"_buckets": {"deposit": "76537a4d-c4c3-4506-bc06-666a7380108e"}, "_deposit": {"created_by": 17, "id": "2002095", "owner": "17", "owners": [17], "owners_ext": {"displayname": "図書情報係", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2002095"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02002095", "sets": ["667"]}, "author_link": [], "control_number": "2002095", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-10-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageStart": "bqab140", "bibliographicVolumeNumber": "162", "bibliographic_titles": [{"bibliographic_title": "Endocrinology", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Energetic status often affects reproductive function, glucose homeostasis, and feeding in mammals. Malnutrition suppresses pulsatile release of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) and increases gluconeogenesis and feeding. The present study aims to examine whether β-endorphin-μ-opioid receptor (MOR) signaling mediates the suppression of pulsatile GnRH/LH release and an increase in gluconeogenesis/feeding induced by malnutrition. Ovariectomized female rats treated with a negative feedback level of estradiol-17β (OVX + low E2) receiving 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, intravenously (iv) were used as a malnutrition model. An administration of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), a selective MOR antagonist, into the third ventricle blocked the suppression of the LH pulse and increase in gluconeogenesis/feeding induced by iv 2DG administration. Histological analysis revealed that arcuate Kiss1 (kisspeptin gene)-expressing cells and preoptic Gnrh1 (GnRH gene)-expressing cells co-expressed little Oprm1 (MOR gene), while around 10% of arcuate Slc17a6 (glutamatergic marker gene)-expressing cells co-expressed Oprm1. Further, the CTOP treatment decreased the number of fos-positive cells in the paraventricular nucleus (PVN) in OVX + low E2 rats treated with iv 2DG but failed to affect the number of arcuate fos-expressing Slc17a6-positive cells. Taken together, these results suggest that the central β-endorphin-MOR signaling mediates the suppression of pulsatile LH release and that the β-endorphin may indirectly suppress the arcuate kisspeptin neurons, a master regulator for GnRH/LH pulses during malnutrition. Furthermore, the current study suggests that central β-endorphin-MOR signaling is also involved in gluconeogenesis and an increase in food intake by directly or indirectly acting on the PVN neurons during malnutrition in female rats.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1210/endocr/bqab140", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is a pre-copyedited, author-produced version of an article accepted for publication in [Endocrinology] following peer review. The version of record [Hitomi Tsuchida, Narumi Kawai, Koki Yamada, Marina Takizawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats, Endocrinology, Volume 162, Issue 10, October 2021, bqab140, https://doi.org/10.1210/endocr/bqab140] is available online at: https://doi.org/10.1210/endocr/bqab140.", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0013-7227", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsuchida, Hitomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawai, Narumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamada, Koki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takizawa, Marina", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inoue, Naoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uenoyama, Yoshihisa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tsukamura, Hiroko", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-10-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Tsuchida_et_al_2021_Endocrinology.pdf", "filesize": [{"value": "20.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 20900000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2002095/files/Tsuchida_et_al_2021_Endocrinology.pdf"}, "version_id": "63ef69fd-3d8e-432e-b50e-a4fac8eab844"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "malnutrition", "subitem_subject_scheme": "Other"}, {"subitem_subject": "kisspeptin neuron", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GnRH neuron", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glutamatergic neuron", "subitem_subject_scheme": "Other"}, {"subitem_subject": "proopiomelanocortin neuron", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["667"], "permalink_uri": "http://hdl.handle.net/2237/0002002095", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-02-14"}, "publish_date": "2022-02-14", "publish_status": "0", "recid": "2002095", "relation": {}, "relation_version_is_last": true, "title": ["Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats"], "weko_shared_id": -1}