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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats

http://hdl.handle.net/2237/0002002095
http://hdl.handle.net/2237/0002002095
ed2aa63a-b3f2-4c0e-bb7a-c669686440c0
名前 / ファイル ライセンス アクション
Tsuchida_et_al_2021_Endocrinology.pdf Tsuchida_et_al_2021_Endocrinology.pdf (20.9 MB)
Item type itemtype_ver1(1)
公開日 2022-02-14
タイトル
タイトル Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats
言語 en
著者 Tsuchida, Hitomi

× Tsuchida, Hitomi

en Tsuchida, Hitomi

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Kawai, Narumi

× Kawai, Narumi

en Kawai, Narumi

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Yamada, Koki

× Yamada, Koki

en Yamada, Koki

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Takizawa, Marina

× Takizawa, Marina

en Takizawa, Marina

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Inoue, Naoko

× Inoue, Naoko

en Inoue, Naoko

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Uenoyama, Yoshihisa

× Uenoyama, Yoshihisa

en Uenoyama, Yoshihisa

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Tsukamura, Hiroko

× Tsukamura, Hiroko

en Tsukamura, Hiroko

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Endocrinology] following peer review. The version of record [Hitomi Tsuchida, Narumi Kawai, Koki Yamada, Marina Takizawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats, Endocrinology, Volume 162, Issue 10, October 2021, bqab140, https://doi.org/10.1210/endocr/bqab140] is available online at: https://doi.org/10.1210/endocr/bqab140.
キーワード
主題Scheme Other
主題 malnutrition
キーワード
主題Scheme Other
主題 kisspeptin neuron
キーワード
主題Scheme Other
主題 GnRH neuron
キーワード
主題Scheme Other
主題 glutamatergic neuron
キーワード
主題Scheme Other
主題 proopiomelanocortin neuron
内容記述
内容記述 Energetic status often affects reproductive function, glucose homeostasis, and feeding in mammals. Malnutrition suppresses pulsatile release of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) and increases gluconeogenesis and feeding. The present study aims to examine whether β-endorphin-μ-opioid receptor (MOR) signaling mediates the suppression of pulsatile GnRH/LH release and an increase in gluconeogenesis/feeding induced by malnutrition. Ovariectomized female rats treated with a negative feedback level of estradiol-17β (OVX + low E2) receiving 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, intravenously (iv) were used as a malnutrition model. An administration of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), a selective MOR antagonist, into the third ventricle blocked the suppression of the LH pulse and increase in gluconeogenesis/feeding induced by iv 2DG administration. Histological analysis revealed that arcuate Kiss1 (kisspeptin gene)-expressing cells and preoptic Gnrh1 (GnRH gene)-expressing cells co-expressed little Oprm1 (MOR gene), while around 10% of arcuate Slc17a6 (glutamatergic marker gene)-expressing cells co-expressed Oprm1. Further, the CTOP treatment decreased the number of fos-positive cells in the paraventricular nucleus (PVN) in OVX + low E2 rats treated with iv 2DG but failed to affect the number of arcuate fos-expressing Slc17a6-positive cells. Taken together, these results suggest that the central β-endorphin-MOR signaling mediates the suppression of pulsatile LH release and that the β-endorphin may indirectly suppress the arcuate kisspeptin neurons, a master regulator for GnRH/LH pulses during malnutrition. Furthermore, the current study suggests that central β-endorphin-MOR signaling is also involved in gluconeogenesis and an increase in food intake by directly or indirectly acting on the PVN neurons during malnutrition in female rats.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1210/endocr/bqab140
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0013-7227
書誌情報 en : Endocrinology

巻 162, 号 10, p. bqab140, 発行日 2021-10
ファイル公開日
日付 2022-10-01
日付タイプ Available
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